After a century of use and abuse of antibiotics, the world is facing antibiotic-resistant bacterial pathogens. In this context, we collectively seek to understand bacterial infections and to identify new ways to fight these infections. Areas of research include the study of virulence factors, the transfer of genetic elements among bacteria, innate immunity to bacterial infections, the study of clinical strains in relation with the patients and the clinical phenotypes. Staphylococcus aureus, Legionella pneumophila, Acinetobacter baumanii, Salmonella typhimurium, Adherent-Invasive Escherichia coli, Francisella tularensis are the main bacterial pathogens being studied in the CIRI.
Particularly, one priority for the specialty is to understand how the diversity among a particular bacterial species can cause different diseases or impact disease dynamics. One technological objective for the specialty is to harness on a larger scale the genetic diversity of environmental and clinical strains (e.g. pathovars) in order to identify the genetic basis of phenotypic traits both experimental (in vitro assays) and clinic (disease presentation and/or outcome) by using bacterial Genome-wide association study (GWAS) and high throughput proteomics.
M Faure (also in Immunology)
T Henry (also in Immunology)