Infectious diseases forum: Pr. Dr. Stefan KUNZ

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Date / Heure
Date(s) - 20/11/2018
10 h 30 min - 11 h 30 min

Emplacement
Amphi Pasteur, Tour CERVI


Prof. Dr. Stefan KUNZ (Institut of microbiology Lausanne University Hospital, Switzerland): “Breaking the barrier: Lassa virus cell invasion

Abstract:
The highly pathogenic arenavirus Lassa virus causes a severe viral hemorrhagic fever and is among the most devastating human pathogens. Lassa virus is of zoonotic origin and reservoir-to-human transmission is crucial for spillover into human populations. Host cell attachment and entry are the first and most fundamental steps of every virus infection and represent major barriers for zoonotic transmission. During host cell invasion, viruses critically depend on cellular factors, including receptors, co-receptors, and regulatory proteins of endocytosis. An in-depth understanding of the complex interaction of a virus with cellular factors implicated in host cell entry is therefore crucial to predict the risk of zoonotic transmission, define the tissue tropism, and assess disease potential. Over the past years, our laboratory investigated the molecular and cellular mechanisms underlying host cell invasion of Lassa virus that uncovered remarkable viral strategies and provided novel insights into viral adaptation and virus-host co-evolution.

Contact: Sylvain BAIZE (sylvain.baize@pasteur.fr)

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