CIRI seminaire: Volker LOHMANN
Date / Heure
Date(s) - 13/02/2018
10 h 45 min - 11 h 45 min
salle des Thèses Chantal Rabourdin-Combes
Volker LOHMANN (University of Heidelberg, Heidelberg – ALLEMAGNE): “ To sense or not to sense: Recognition of Hepatitis C virus RNA by TLR3 ”
Hepatitis C virus (HCV) infections most often result in chronic outcomes, although the virus constantly produces replication intermediates, in particular double-stranded RNA (dsRNA), representing potent inducers of innate immunity. We have characterized the fate of HCV-derived replication intermediates in hepatocyte cultures to understand the mechanisms contributing to viral persistence in presence of an active innate immune response. Our results indicate that part of the HCV dsRNA intermediates are released from infected cells in extracellular vesicles attenuating activation of TLR3 in HCV-infected cells. This mechanism represents a novel strategy to dampen intracellular innate immune responses, potentially contributing to the establishment of persistence.
Contact : Marlene Dreux