CIRI Seminar: Pr. Joan YUAN

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Date / Heure
Date(s) - 27/11/2019
11 h 00 min - 12 h 00 min

Emplacement
Amphi Pasteur, Tour CERVI


Pr. Joan YUAN (Lund University – Division of molecular hematology
Lund – SWEDEN) : “ Long-term lineage tracing of neonatal B cells in health and disease ”.

Abstract:
A wave of long-lived B cells enter the B cell lineage shortly after birth. These early life derived B cells are unevenly scattered across different anatomical locations and are often tissue resident. Their selection into the neonatal B cell repertoire occurs under relaxed tolerance constraints in a Lin28b dependent Fashion (1). Our findings reveal a new way of stratifying the adult B cell compartment, based on cellular turnover, with important implications in health and disease
(1) Vanhee et al. Lin28b controls a neonatal to adult switch in B cell positive selection. 2019, Science Immunology

 

contact : thierry.defrance@inserm.fr

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