CIRI seminar: Dr. Baptiste JAEGER
Date / Heure
Date(s) - 04/11/2019
11 h 00 min - 12 h 00 min
Amphi Pasteur, Tour CERVI
Dr. Baptiste JAEGER (Brain Research Institut, Université de Zurich – Suisse): “ Encoding more than memories in the hippocampus ”
The hippocampus is a brain region critical for learning and memory. Typically, behavioral stimulations – such as exposure to a novel environment (NE) – trigger neuronal activation and subsequent memory encoding in the hippocampus. We combined flow cytometry and single nucleus RNA sequencing of activated hippocampal neurons following NE exposure, to dissect the molecular changes at the basis of memory formation. Our results demonstrate that activity-induced transcriptional changes select the components of the neuronal network that are ultimately involved in the encoding and retrieval of memories. Using our extensive characterization of the neuronal population encoding NE as the gold-standard mechanism of memory formation, we are now exploring the processing of other types of natural stimulations. In particular, we aim to uncover how the brain processes peripheral changes in immune homeostasis and feeds back on the immune system.
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