CIRI seminar: Dr. Saidi HOMA SOUDJA
Date / Heure
Date(s) - 19/11/2019
11 h 00 min - 12 h 00 min
salle des Thèses Chantal Rabourdin-Combes
Dr. Saidi HOMA SOUDJA (CRCL): “ The dialogue between conventional T cells and Intestinal Epithelial Cells ”
Dysregulated immune responses against commensal bacteria have been associated to inflammatory bowel disease (IBD). Among immune cells, the activation of CD8ab T cells correlates with the worse experiences of IBDs in human patients. Thus, deciphering what regulate CD8ab T cell activation within the intestine is a major challenge (1).
In the gut, intestinal epithelial cells (IECs) establish a link between commensal bacteria and mucosal immune system, and particular conventional T cells. IECs are equipped with innate sensor machineries such as Toll Like Receptors (TLRs). IECs could also express the antigen processing machinery such as the immunoproteasome. As a result, IECs are able to efficiently sense the tremendous quantity of microbes hosted in the gut. It is a constant challenge to control IEC reactivity to commensal bacteria and avoid inappropriate immune reaction and IBD development. However, the mechanisms by which intestinal epithelial cell responses to microbiota are tuned remain elusive (2).
Globally, we are deciphering the cues of the dialogue between conventional T cells and intestinal epithelial cells in homeostatic condition or in pathological settings.
contact : henri.gruffat-at-ens-lyon.fr