CIRI seminar: Dr Stoyan IVANOV
Date / Heure
Date(s) - 11/10/2019
10 h 00 min - 11 h 00 min
Amphi Pasteur, Tour CERVI
Dr Stoyan IVANOV (U1065 ; Université de Nice) “ Metabolic control of monocyte and macrophage functions ”
Monocyte and macrophage diversity is evidenced by the modulation of cell surface markers and differential production of soluble mediators. These immune cells play key roles in controlling tissue homeostasis, infections, and excessive inflammation. Recently, it became clear that metabolism controls macrophage and monocyte main functions. Modulation of glucose, fatty acid, and amino acid metabolism is associated with various macrophage activations in response to external stimuli. Modulation of environmental factors impacts on immune cell numbers and functions. Warm ambient temperature is atheroprotective and thermoneutrality associates with reduced monocyte egress from the bone marrow in mice and likewise may also suppress blood monocyte counts in man.
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