CIRI seminar: Mathilde GENDRIN
Date / Heure
Date(s) - 28/05/2018
14 h 00 min - 15 h 00 min
salle des Thèses Chantal Rabourdin-Combes
Mathilde GENDRIN (Institut Pasteur – Guyane): “ The mosquito microbiota and its impact on disease transmission ”
A mosquito’s efficiency to transmit a disease depends on its permissiveness to the pathogen as well as on its probability to live through the incubation period of the pathogen and subsequently bite new hosts. These parameters are not only controlled by immunity but also affected by the microbiota. In particular, the microbiota of Anopheles mosquitoes negatively affects infection by Plasmodium by inducing mosquito immunity, producing antimicrobials and promoting oxidative stress. The composition of the microbiota in laboratory-reared mosquitoes is however very different to that of field mosquitoes, suggesting the need for better models to study the microbiota and its impact on disease transmission. I will review the current knowledge on the interactions between the mosquito, its microbiota and Plasmodium and introduce how my starting laboratory in French Guiana (Amazon basin) is combining fieldwork and gnotobiology to study such interactions on local vectors of malaria and arboviruses.
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