Infectious Diseases Forum: Dr. Franck KIRCHHOFF
Date / Heure
Date(s) - 05/11/2019
11 h 00 min - 12 h 00 min
Amphi Pasteur, Tour CERVI
Dr. Franck KIRCHHOFF (Institut of Molecular Virology, Ulm University Medical Center, Ulm– RFA): “ Novel restriction factors targeting HIV-1 dependencies ”
HIV, the causative agent of AIDS, has a complex evolutionary history involving several cross-species transmissions and recombination events as well as changes in the repertoire and function of its accessory genes. Understanding the factors and adaptations required for the spread of HIV in the human population provides key insights into innate defence mechanisms and prerequisites for the emergence of the AIDS pandemic. Here, I will first briefly summarize some of our current knowledge on the function of antiviral restriction factors and their viral antagonists, i.e. the accessory viral factors Vpr, Vpx, Vpu and Nef. Next, I will discuss viral features and adaptations preceding the AIDS pandemic. Finally, I will present examples for novel interferon-inducible antiviral factors that modulate the activity of virus-dependency factors rather than targeting the virus directly. Altogether, it is becoming evident that the mechanisms of viral restriction as well as viral countermeasures are even more complex and intertwined than anticipated, and apparently still play relevant roles in the spread of HIV/AIDS.
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