PhD defence: Mathieu CLAVIERE

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Date / Heure
Date(s) - 25/06/2018
14 h 00 min

Amphi Pasteur, Tour CERVI

PhD defence: Mathieu CLAVIERE, team «Autophagy, Infections & Immunity», Monday June 25th in Amphi Pasteur, tour CERVI at 14h00.

« Study of autophagy during co-infection between Measles virus and Salmonella typhimurium. »

Measles virus is a pathogenic agent responsible for transient but severe immunosuppression in infected individuals. The infection can lead to the establishment of secondary infections, frequently described in measles virus infected patients. Nevertheless, Measles virus contribution to secondary infection at cell scale level have never been studied yet. Our team has previously described that Measles virus induce a fully functional autophagy in infected cells, which is mandatory for an efficient viral replication. On the opposite, some pathogens, as the bacteria Salmonella typhimurium are restricted by autophagy. The aim of this PhD project is to study the contribution of autophagy on bacterial proliferation upon Measles virus co-infection at cell level. During this project, we have identified that in Measles virus coinfected cells, Salmonella typhimurium hyperproliferates. This exacerbated proliferation takes place in multinucleated giant cells induced by the virus, which are called syncytia. In addition, the bacteria, which is normally localized in cellular vacuole, is localized directly inside the cytosol of syncytia. Furthermore, cytosolic bacteria appears to be insensitive to autophagy. During this PhD project, we have identified that the cellular factor TBK1 could be hijack by the viral infection. Thus, this could allow the auophagic escape of the bacteria. This study highlight a new opportunity of autophagic escape of bacteria during a viral co-infection.


Jury members:
Pr Mollereau, Bertrand / Professeur à l’ENS de Lyon / Examinateur
Pr Esclatine, Audrey / Professeure à l’Université Paris sud /Rapporteure
Dr Vergne, Isabelle /Chargée de recherche au CNRS /Rapporteure
Dr Nguyen, Hang /Chargée de recherche à l’INSERM /Examinatrice
Pr Faure, Mathias /Professeur à l’Université Claude Bernard /Directeur de thèse