PhD defence: Mathilde CALVEZ

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Date / Heure
Date(s) - 02/07/2018
14 h 00 min - 17 h 00 min

Amphi Pasteur, Tour CERVI

PhD defence: Mathilde CALVEZ , team « Immunity and cytotoxic lymphocytes»,Monday July 1st in Amphi Pasteur, tour CERVI at 14h00.

« Role of Pleckstrin protein in the generation and tissue localization of memory CD8 T cells. »

CD8 T cells are key players of adaptive immunity, and are involved in the elimination of intracellular pathogens and cancer cells. During a primary immune response, memory CD8 T cells are generated, and are able to maintain long-term and protect efficiently the organism against a secondary encounter with these threats. Indeed, memory CD8 T cells mediate durable protection through enhanced effector functions, increased proliferative capacity and distinct migratory behaviors, three processes that are tightly regulated by actin cytoskeleton.
Recently, the laboratory has shown that pleckstrin, a gene involved in actin cytoskeleton, is highly up-regulated in pathogen-induced memory CD8 T cells compared to naïve cells. Using pleckstrin deficient CD8 T cells, we show in an in vivo model of Vaccinia virus infection that pleckstrin deficiency does not affect global CD8 functions, in terms of cytokine production and cytotoxicity. However, pleckstrin is required for the optimal generation and localization of memory CD8 T cells within infected tissues.
As a whole, this work gives new insight into the molecular and cellular mechanisms that allow the establishment of a memory CD8 T cell compartment within non-lymphoid tissues.


Jury members:
Dr. Salvatore VALITUTTI, Directeur de recherche à l’Inserm, Rapporteur
Dr. Grégory VERDEIL, Principal investigator à l’UNIL, Rapporteur
Dr. Karine CROZAT, Chargée de recherche au CNRS, Examinatrice
Dr. Ana-Maria LENNON-DUMENIL, Directrice de recherche à l’Inserm, Examinatrice
Pr. Mathias FAURE, Professeur à l’UCBL, Examinateur
Dr. Mélanie WENCKER, Chargée de recherche à l’Inserm, Directrice de thèse
Dr. Jacqueline MARVEL, Directrice de recherche au CNRS, Co-encadrante