Innate Immunity in infectious and autoimmune diseases

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Publications

High mTOR activity is a hallmark of reactive natural killer cells and amplifies early signaling through activating receptors.
Marçais A, Marotel M, Degouve S, Koenig A, Fauteux-Daniel S, Drouillard A, Schlums H, Viel S, Besson L, Allatif O, Bléry M, Vivier E, Bryceson Y, Thaunat O, Walzer T.
Elife. 2017 Aug 30;6. pii: e26423. doi: 10.7554/eLife.26423.

Alteration of Natural Killer cell phenotype and function in obese individuals. Viel S, Besson L, Charrier E, Marçais A, Disse E, Bienvenu J, Walzer T, Dumontet C. Clin Immunol. 2016 Jan 18. pii: S1521-6616(16)30006-7. doi: 10.1016/j.clim.2016.01.007.

NKp46+ Innate Lymphoid Cells Dampen Vaginal CD8 T Cell Responses following Local Immunization with a Cholera Toxin-Based Vaccine. Luci C, Bekri S, Bihl F, Pini J, Bourdely P, Nouhen K, Malgogne A, Walzer T, Braud VM, Anjuère F.PLoS One. 2015 Dec 2;10(12):e0143224. doi: 10.1371/journal.pone.0143224. eCollection 2015.

Terminal NK cell maturation is controlled by concerted actions of T-bet and Zeb2 and is essential for melanoma rejection. van Helden MJ, Goossens S, Daussy C, Mathieu AL, Faure F, Marçais A, Vandamme N, Farla N, Mayol K, Viel S, Degouve S, Debien E, Seuntjens E, Conidi A, Chaix J, Mangeot P, de Bernard S, Buffat L, Haigh JJ, Huylebroeck D, Lambrecht BN, Berx G, Walzer T. J Exp Med. 2015 Nov 16;212(12):2015-25. doi: 10.1084/jem.20150809.

Inherited anomalies of innate immune receptors in pediatric-onset inflammatory diseases.Picard C, Mathieu AL, Hasan U, Henry T, Jamilloux Y, Walzer T, Belot A. Autoimmun Rev. 2015 Dec;14(12):1147-53. doi: 10.1016/j.autrev.2015.08.002.

PRKDC mutations associated with immunodeficiency, granuloma, and autoimmune regulator-dependent autoimmunity.Mathieu AL, Verronese E, Rice GI, Fouyssac F, Bertrand Y, Picard C, Chansel M, Walter JE, Notarangelo LD, Butte MJ, Nadeau KC, Csomos K, Chen DJ, Chen K, Delgado A, Rigal C, Bardin C, Schuetz C, Moshous D, Reumaux H, Plenat F, Phan A, Zabot MT, Balme B, Viel S, Bienvenu J, Cochat P, van der Burg M, Caux C, Kemp EH, Rouvet I, Malcus C, Méritet JF, Lim A, Crow YJ, Fabien N, Ménétrier-Caux C, De Villartay JP, Walzer T, Belot A. J Allergy Clin Immunol. 2015 Jun;135(6):1578-88.e5. doi: 10.1016/j.jaci.2015.01.040.

mTOR: a gate to NK cell maturation and activation.Marçais A, Walzer T. Cell Cycle. 2014;13(21):3315-6. doi:10.4161/15384101.2014.972919.

microRNA-mediated regulation of mTOR complex components facilitates discrimination between activation and anergy in CD4 T cells. Marcais A, Blevins R, Graumann J, Feytout A, Dharmalingam G, Carroll T, Amado IF, Bruno L, Lee K, Walzer T, Mann M, Freitas AA, Boothby M, Fisher AG, Merkenschlager M. J Exp Med. 2014 Oct 20;211(11):2281-95. doi: 10.1084/jem.20132059.

Mutations in CECR1 associated with a neutrophil signature in peripheral blood. Belot A, Wassmer E, Twilt M, Lega JC, Zeef LA, Oojageer A, Kasher PR, Mathieu AL, Malcus C, Demaret J, Fabien N, Collardeau-Frachon S, Mechtouff L, Derex L, Walzer T, Rice GI, Durieu I, Crow YJ. Pediatr Rheumatol Online J. 2014 Sep 24;12:44. doi: 10.1186/1546-0096-12-44.

Human natural killer cells promote cross-presentation of tumor cell-derived antigens by dendritic cells. Deauvieau F, Ollion V, Doffin AC, Achard C, Fonteneau JF, Verronese E, Durand I, Ghittoni R, Marvel J, Dezutter-Dambuyant C, Walzer T, Vie H, Perrot I, Goutagny N, Caux C, Valladeau-Guilemond J. Int J Cancer. 2014 Jul 21. doi: 10.1002/ijc.29087.

The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells. Marçais A, Cherfils-Vicini J, Viant C, Degouve S, Viel S, Fenis A, Rabilloud J, Mayol K, Tavares A, Bienvenu J, Gangloff YG, Gilson E, Vivier E, Walzer T. Nat Immunol. 2014 Aug;15(8):749-57. doi: 10.1038/ni.2936.

Dok1 and Dok2 proteins regulate natural killer cell development and function. EMBO J. Celis-Gutierrez J, Boyron M, Walzer T, Pandolfi PP, Jonjić S, Olive D, Dalod M, Vivier E, Nunès JA.2014 Sep 1;33(17):1928-40. doi: 10.15252/embj.201387404.

T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow. Daussy C, Faure F, Mayol K, Viel S, Gasteiger G, Charrier E, Bienvenu J, Henry T, Debien E, Hasan UA, Marvel J, Yoh K, Takahashi S, Prinz I, de Bernard S, Buffat L, Walzer T. J Exp Med. 2014 Mar 10;211(3):563-77. doi: 10.1084/jem.20131560.

Regulation of mouse NK cell development and function by cytokines. Marçais A, Viel S, Grau M, Henry T, Marvel J, Walzer T.Front Immunol. 2013 Dec 12;4:450. doi: 10.3389/fimmu.2013.00450. Review.

CCR1 inhibition ameliorates the progression of lupus nephritis in NZB/W mice. Bignon A, Gaudin F, Hémon P, Tharinger H, Mayol K, Walzer T, Loetscher P, Peuchmaur M, Berrebi D, Balabanian K.J Immunol. 2014 Feb 1;192(3):886-96. doi:10.4049/jimmunol.1300123.

Monitoring NK cell activity in patients with hematological malignancies. Viel S, Charrier E, Marçais A, Rouzaire P, Bienvenu J, Karlin L, Salles G, Walzer T. Oncoimmunology. 2013 Sep 1;2(9):e26011.

ASC controls IFN-gamma levels in an IL-18-dependent manner in caspase-1-deficient mice infected with Francisella novicida.
Pierini R, Perret M, Djebali S, Juruj C, Michallet MC, Forster I, Marvel J,Walzer T, Henry T.
J Immunol. 2013 Oct 1;191(7):3847-57.

S1PR5 is pivotal for the homeostasis of patrolling monocytes.
Debien E, Mayol K, Biajoux V, Daussy C, De Aguero MG, Taillardet M, Dagany N, Brinza L, Henry T, Dubois B, Kaiserlian D, Marvel J, Balabanian K, Walzer T.
Eur J Immunol. 2013 Jun;43(6):1667-75. doi: 10.1002/eji.201343312.

Negative regulation of NKG2D expression by IL-4 in memory CD8 T cells.
Ventre E, Brinza L, Schicklin S, Mafille J, Coupet CA, Marçais A, Djebali S, Jubin V, Walzer T, Marvel J.
J Immunol. 2012 Oct 1;189(7):3480-9.

[Homeostasis of natural killer cells].
Rouzaire P, Mayol K, Viel S, Bienvenu J, Walzer T.
Med Sci (Paris). 2012 Apr;28(4):403-8. doi: 10.1051/medsci/2012284018.

T inflammatory memory CD8 T cells participate to antiviral response and generate secondary memory cells with an advantage in XCL1 production.
Jubin V, Ventre E, Leverrier Y, Djebali S, Mayol K, Tomkowiak M, Mafille J, Teixeira M, Teoh DY, Lina B, Walzer T, Arpin C, Marvel J.
Immunol Res. 2012 Jun;52(3):284-93. doi: 10.1007/s12026-012-8340-4.

Fate mapping analysis of lymphoid cells expressing the NKp46 cell surface receptor.
Narni-Mancinelli E, Chaix J, Fenis A, Kerdiles YM, Yessaad N, Reynders A, Gregoire C, Luche H, Ugolini S, Tomasello E, Walzer T, Vivier E.
Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18324-9. doi: 10.1073/pnas.1112064108.

Natural killer cells and T cells induce different types of skin reactions during recall responses to haptens.
Rouzaire P, Luci C, Blasco E, Bienvenu J, Walzer T, Nicolas JF, Hennino A.
Eur J Immunol. 2012 Jan;42(1):80-8. doi: 10.1002/eji.201141820.

Sequential desensitization of CXCR4 and S1P5 controls natural killer cell trafficking.
Mayol K, Biajoux V, Marvel J, Balabanian K, Walzer T.
Blood. 2011 Nov 3;118(18):4863-71. doi: 10.1182/blood-2011-06-362574.

G-protein-coupled receptors in control of natural killer cell migration.
Walzer T, Vivier E.
Trends Immunol. 2011 Oct;32(10):486-92. doi: 10.1016/j.it.2011.05.002.

Confinement of activating receptors at the plasma membrane controls natural killer cell tolerance.
Guia S, Jaeger BN, Piatek S, Mailfert S, Trombik T, Fenis A, Chevrier N, Walzer T, Kerdiles YM, Marguet D, Vivier E, Ugolini S.
Sci Signal. 2011 Apr 5;4(167):ra21. doi: 10.1126/scisignal.2001608.

Monocytes control natural killer cell differentiation to effector phenotypes.
Soderquest K, Powell N, Luci C, van Rooijen N, Hidalgo A, Geissmann F, Walzer T, Lord GM, Martín-Fontecha A.
Blood. 2011 Apr 28;117(17):4511-8. doi: 10.1182/blood-2010-10-312264

Cutting edge: CD8+ T cell priming in the absence of NK cells leads to enhanced memory responses.
Soderquest K, Walzer T, Zafirova B, Klavinskis LS, Polić B, Vivier E, Lord GM, Martín-Fontecha A.
J Immunol. 2011 Mar 15;186(6):3304-8. doi: 10.4049/jimmunol.1004122.

Genetic labeling reveals altered turnover and stability of innate lymphocytes in latent mouse cytomegalovirus infection.
Busche A, Schmitz S, Fleige H, Robbins SH, Walzer T, Stewart CA, Förster R, Messerle M, Prinz I.
J Immunol. 2011 Mar 1;186(5):2918-25. doi: 10.4049/jimmunol.1003232.

Natural killer cells accumulate in lung-draining lymph nodes and regulate airway eosinophilia in a murine model of asthma.
Ple C, Barrier M, Amniai L, Marquillies P, Bertout J, Tsicopoulos A, Walzer T, Lassalle P, Duez C.
Scand J Immunol. 2010 Aug;72(2):118-27. doi: 10.1111/j.1365-3083.2010.02419.x.

CD137 in NK cells.
Marvel J, Walzer T.
Blood. 2010 Apr 15;115(15):2987-8. doi: 10.1182/blood-2010-01-261404.

NK-cell education: KIR-S come into play.
Walzer T.
Blood. 2010 Feb 11;115(6):1110-1. doi: 10.1182/blood-2009-11-254953.

Interactions between human NK cells and macrophages in response to Salmonella infection.
Lapaque N, Walzer T, Méresse S, Vivier E, Trowsdale J.
J Immunol. 2009 Apr 1;182(7):4339-48. doi: 10.4049/jimmunol.0803329.

Maturation of mouse NK cells is a 4-stage developmental program.
Chiossone L, Chaix J, Fuseri N, Roth C, Vivier E, Walzer T.
Blood. 2009 May 28;113(22):5488-96. doi: 10.1182/blood-2008-10-187179.

Mouse CD146/MCAM is a marker of natural killer cell maturation.
Despoix N, Walzer T, Jouve N, Blot-Chabaud M, Bardin N, Paul P, Lyonnet L, Vivier E, Dignat-George F, Vély F.
Eur J Immunol. 2008 Oct;38(10):2855-64. doi: 10.1002/eji.200838469.

Cutting edge: Priming of NK cells by IL-18.
Chaix J, Tessmer MS, Hoebe K, Fuséri N, Ryffel B, Dalod M, Alexopoulou L, Beutler B, Brossay L, Vivier E, Walzer T.
J Immunol. 2008 Aug 1;181(3):1627-31.

Intrasplenic trafficking of natural killer cells is redirected by chemokines upon inflammation.
Grégoire C, Cognet C, Chasson L, Coupet CA, Dalod M, Reboldi A, Marvel J, Sallusto F, Vivier E, Walzer T.
Eur J Immunol. 2008 Aug;38(8):2076-84. doi: 10.1002/eji.200838550.

Functions of natural killer cells.
Vivier E, Tomasello E, Baratin M, Walzer T, Ugolini S.
Nat Immunol. 2008 May;9(5):503-10. doi: 10.1038/ni1582.

Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling.
Robbins SH, Walzer T, Dembélé D, Thibault C, Defays A, Bessou G, Xu H, Vivier E, Sellars M, Pierre P, Sharp FR, Chan S, Kastner P, Dalod M.
Genome Biol. 2008 Jan 24;9(1):R17. doi: 10.1186/gb-2008-9-1-r17.

Patents

1. International patent: WO 2006 / 103569 A2 : Expression vectors and methods for obtaining NK cell-specific expression, co-inventor.

2. INSERM Licence Genway Biotech Dossier 06332 A10, coinventor

3. International Patent : WO/2009/053481 compositions and methods for modulatingT and NK cell trafficking