Immunity and cytotoxic lymphocytes
CD8 T lymphocytes are an essential component of the protective adaptive-immunity against viral infections and tumour development. The generation of long-term immunity against many pathogens is dependent on the formation of a diversity of long-lived memory CD8 T cells. Memory CD8 T cells can be defined as antigen-experienced cells that display an improved response as compared to naïve cells. Indeed, memory CD8+ T cells differ from naïve cells by a number of properties. They acquire a new surface phenotype that is associated with new trafficking patterns, increased responsiveness to pathogens resulting from accelerated capacity to enter cell division and to display effector functions such as cytokine secretion or cytolytic activity. Our current goals are to establish the phenotypic and functional characteristics associated with memory CD8 T cell differentiation, as well as the factors, associated with the primary response, that control the acquisition of these modifications. This knowledge is key to the development of vaccines aimed at inducing an efficient CD8 immune response.
- Identification of a new subset of memory CD8 T cells induced under sterile inflammation (T inflammatory memory)
- Demonstration that newly generated pre-cDC need to be licensed by inflammatory signals (GM-CSF or PAMP) for the activation of the class I cross-presentation pathway and the stimulation of CD8 T cells
- TLR2 act as a costimulatory molecule that regulates naive and memory CD8 T cell activation (collaboration with the team of Dr N.Bonnefoy)
- Identification of biomarkers for pathogen-induced memory cells (Patent submitted)
- Gene expression signature associated with protective pathogen-specific memory CD8+ T cells.
- Demonstration that deregulation of Sp1-expression leads to the activation of a cell-intrinsic innate-immune response that precedes cell-cycle perturbation and apoptosis
- Modelling of CD8 T cell immune response
INSERM, UCBL, CNRS, ANR, FINOVI, ARC, LNCC.