Inflammasome, bacterial infections and autoinflammation

Afficher tout

Main Publications

(For the full updated list of publications see: GoogleScholar_T_HENRY)

A genome-wide screen identifies IRF2 as a key regulator of caspase-4 in human cells.
Benaoudia S, Martin A, Puig Gamez M, Gay G, Lagrange B, Cornut M, Krasnykov K, Claude JB, Bourgeois CF, Hughes S, Gillet B, Allatif O, Corbin A, Ricci R, Henry T.
EMBO Rep. 2019 Jul 29

A Proximity-Dependent Biotinylation (BioID) Approach Identifies p62/SQSTM1 as a Caspase-1 Substrate
Jamilloux Y, Lagrange B, Di Micco A, Bourdonnay E, Provost A, Talant R, Henry T@, and Martinon F@
@Co-corresponding author
JBC 2018 Aug 10;293(32):12563-12575

Human CD45 is an F-Component-specific receptor for the staphylococcal toxin Panton-Valentine leukocidin
Tromp AT, Van Gent M, Abrial P, Martin A, Jansen JP, De Haas CJC, Van Kessel KPM, Bardoel BW, Kruse E, Bourdonnay E, Boettcher M, McManus MT, Day CJ, Jennings M, Vandenesch F, Van Strijp JAG, Lebbink RJ, Haas PJA, Henry T@, Spaan AN @.
@Co-Senior authors
Nat Microbiol. 2018 May 7;

Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11.
Lagrange B, Benaoudia S, Wallet P, Magnotti F, Provost A, Michal F, Martin A, Di Lorenzo F, Py BF, Molinaro A, Henry T.
Nat Commun. 2018 Jan 16;9(1):242. doi: 10.1038/s41467-017-02682-y.

IFN-γ extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection.
Wallet P, Benaoudia S, Mosnier A, Lagrange B, Martin A, Lindgren H, Golovliov I, Michal F, Basso P, Djebali S, Provost A, Allatif O, Meunier E, Broz P, Yamamoto M, Py BF, Faudry E, Sjöstedt A, Henry T.
PLoS Pathog. 2017 Oct 2;13(10):e1006630. doi: 10.1371/journal.ppat.1006630.

Francisella tularensis IglG Belongs to a Novel Family of PAAR-Like T6SS Proteins and Harbors a Unique N-terminal Extension Required for Virulence.
Rigard M, Bröms JE, Mosnier A, Hologne M, Martin A, Lindgren L, Punginelli C, Lays C, Walker O, Charbit A, Telouk P, Conlan W, Terradot L, Sjöstedt A, Henry T.
PLoS Pathog. 2016 Sep 7;12(9):e1005821. doi: 10.1371/journal.ppat.1005821.

Staphylococcus aureus Targets the Duffy Antigen Receptor for Chemokines (DARC) to Lyse Erythrocytes.
Spaan AN*, Reyes-Robles T*, Badiou C, Cochet S, Boguslawski KM, Yoong P, Day CJ, de Haas CJ, van Kessel KP, Vandenesch F, Jennings MP, Le Van Kim C, Colin Y, van Strijp JA, Henry T@, Torres VJ@.
*Co-First authors;@Co-Senior authors
Cell Host Microbe. 2015 Aug 26. pii: S1931-3128(15)00309-1. doi: 10.1016/j.chom.2015.08.001.

GBPs promote AIM2 inflammasome activation during Francisella infection by inducing cytosolic bacteriolysis and DNA release.
Meunier E*, Wallet P*, Dreier RF, Costanzo S, Anton L, Rühl S, Dick MS, Dussurget S, Kistner A, Rigard M, Degrandi D, Pfeffer K, Yamamoto M, Henry T@, Broz P@
*Co-First authors; @Co-Senior authors
Nature Immunology. 2015 May 16(5):476-84. doi:10.1038/ni.3119.

The staphylococcal toxins γ-haemolysin AB and CB differentially target phagocytes by employing specific chemokine receptors.
Spaan AN, Vrieling M, Wallet P, Badiou C, Reyes-Robles T, Ohneck EA, Benito Y, de Haas CJ, Day CJ, Jennings MP, Lina G, Vandenesch F, van Kessel KP, Torres VJ, van Strijp JA, Henry T.
Nat Commun. 2014 Nov 11;5:5438. doi: 10.1038/ncomms6438.

ASC controls IFN-gamma levels in an IL-18-dependent manner in Caspase-1-deficient mice infected with Francisella novicida.
Pierini R., Perret M., Djebali S., Juruj C., Michallet M.C., Förster I., Marvel J.M., Walzer T., Henry T
The Journal of Immunology.2013 Oct 1;191(7):3847-57. doi: 10.4049/jimmunol.1203326

AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages.
Pierini R, Juruj C, Perret M, Jones CL, Mangeot P, Weiss DS, Henry T.
Cell Death Differ. 2012 Oct;19(10):1709-21. doi: 10.1038/cdd.2012.51.

Cross-talk between Staphylococcus aureus leukocidins-intoxicated macrophages and lung epithelial cells triggers chemokine secretion in an inflammasome-dependent manner.
Perret M, Badiou C, Lina G, Burbaud S, Benito Y, Bes M, Cottin V, Couzon F, Juruj C, Dauwalder O, Goutagny N, Diep BA, Vandenesch F, Henry T.
Cell Microbiol. 2012 Jul;14(7):1019-36. doi: 10.1111/j.1462-5822.2012.01772.x.

Type I IFN signaling constrains IL-17A/F secretion by gammadelta T cells during bacterial infections.
Henry T, Kirimanjeswara GS, Ruby T, Jones JW, Peng K, Perret M, Ho L, Sauer JD, Iwakura Y, Metzger DW, Monack DM.
J Immunol. 2010 Apr 1;184(7):3755-67. doi: 10.4049/jimmunol.0902065.