UE Europe « Virus & Immunity »
VIRUS AND IMMUNITY, European teaching unit
The « Virus & Immunity » Course is organized as part of the European Master-Biosciences program in Lyon, France.
Course « Virus and Immunity » is organized for the first time in April 2005, as a part of « European » teaching unit. It is open to students of « Masters » in at Ecole Normale Supérieure de Lyon and University Lyon 1 as well as to any other exchange students, particularly those from other European countries and intended to stimulate international students participation. The course consists of 40h of lectures and 10h of tutorials (giving 6 credits ECTS). All lectures are given on english by the experts in the field (three Nobel prize laureates among lecturers in last years) and are based on the interactive approach between lecturers and students. Tutorials are supposed to help students to better understand subjects treated during lectures. Organized teaching approach is supposed to guide students in the analysis of research articles and in preparing a short research project based on one of conferences. The major goal of the course is to stimulate the originality in students and help developing their passion for the research and creative approach in the science, by guiding them through the universe of the complex interactions between the virus and the immune system.
Programme of the course:
The course covers different aspects of fundamental virology and immunology and particular attention is put on the interaction between virus and immune system. Treated subjects include analysis of biochemical and structural aspects of the virus, variability and genetics, basic concepts in the prion research, response to anti-viral treatment and generation of the resistance to therapy. Presented studies include the research work on several different viruses, including causative agent of AIDS in humans and of leukaemia in mice, hepatitis B and C virus, Infuenza, Measles virus, Human T-cell Lymphotropic virus and emergent viruses classified at the highest level of security (P4), including Ebola, Lassa, SARS, Nipah and Hendra viruses. Particular attention is put on the presentation of the importance of different self-defence mechanisms to eliminate infection, including dendritic cells, T and NK lymphocytes as well as mechanisms important in the control of the extent of the immune response, like T regulatory lymphocytes. Generation of T cell repertoire, immunological memory, modulation of the immune response, virus escape mechanisms, immunosuppression and viral persistence is illustrated. Finally, viral pathogenesis and anti-viral vaccination is discussed.
1-12/02/2016, amphitheater « Biologie », ENS-Lyon, France
9H30-10H Introduction (V. Volchkov, B. Horvat, CIRI, INSERM U1111, Lyon)
10H-12H Grant McFADDEN (Depart. Molecular Genetics and Microbiology, University of
Florida, USA), LabEx ECOFECT
«Lessons from Myxoma Virus on Viral-Host Ecology and Co-evolution»
14H-16H30 Alexandra R. LUCAS (University of Florida, USA)
“Viral Immune Modulators – Guides to New Drug Discovery ».
9H30-12H Sandra JUNGLEN (Institut of Virology, Bonn, Germany, LabEx ECOFECT.
« Evolutionary and ecological insights into the emergence of arthropod-borne viruses »
14H-16H30 Siamon GORDON (Sir William Dunn School of Pahtology, University of Oxford, UK)
« The Versatile Macrophage: Immunobiology/virology»
9H30-12H Thierry WALZER (CIRI, INSERM U1111, Lyon)
« NK cells in the control of infections »
14H-16H30 Branka HORVAT (CIRI, INSERM U1111, ECOFECT, Lyon)
«Emerging contagion: immunopathogenesis of Nipah virus infection»
9H30-12H Adrian HAYDAY (Guy’s King’s & St Thomas Medical School, London, UK)
« Gamma Delta T cell responses bridge innate and adaptive immunity »
14H-16H30 Daniel GONZALEZ-DUNIA (INSERM, UMR 1043, Toulouse)
« A journey through the interactions between viruses and the brain: advantages and
challenges of the Bornavirus paradigm ».
9H30-12H Julien C. MARIE (Cancer Research Center, Lyon, INSERM 1052 CNRS 5286)
« TGF-beta and regulation of the immune response»
14H30-17H Maan ZREIN (INFYNITY-BIOMARKERS, Lyon, France)
« Converting academic research into industrial applications: Design of diagnostics
assays with a focus on virology »
9H30-12H Benedikt KAUFER (Institute of Virology, Berlin, Germany)
«Herpesvirus latency: From neuronal models to integration into host telomeres. »
14-18H ROUND TABLE (Viktor VOLCHKOV, CIRI Lyon)
9H30-12H Daniel KOLAKOFSKY (Department of Microbiology and Molecular Medicine,
University of Geneva Medical School, Geneva, Switzerland :
« A short biased history of RNA viruses
14H-16H30 Patrick LOMONTE (Institut NeuroMyoGène, INSERM-U1217, CNRS/UCBL,
« Immune and epigenetic control of herpes simplex virus latency»
9h30-12H Sander HERFST (Department of Viroscience, Erasmus Medical Centre, Netherlands)
« Influenza: From zoonoses to pandemics»
14H-16H30 François-Loïc COSSET (CIRI, INSERM U1111, ECOFECT, Lyon)
« HCV-lipid metabolism interconnections and virus propagation: opportunities for the
development of novel antiviral strategies »
9H30-12H Viktor VOLCHKOV (CIRI, INSERM U1111, ECOFECT, Lyon)
« Filoviruses: Molecular basis of the pathogenicity».
14H-16H Written examination, ENS-Lyon