FINOVI keynote seminar : Prof. David W. HOLDEN
Date / Heure
Date(s) - 22/11/2017
11 h 00 min - 12 h 00 min
salle des Thèses Chantal Rabourdin-Combes
Prof. David W. HOLDEN (MRC Centre for Molecular Bacteriology and Infection, Imperial College London): ” Suppression of adaptive immunity by Salmonella ”
Salmonella enterica can cause persistent infections such as typhoid fever. Following bacterial entry into host cells, the pathogen replicates in a membrane-bound compartment called the Salmonella-containing vacuole (SCV). Bacteria respond to nutritional deprivation and the acidic pH in the vacuole lumen by activating the expression of the SPI-2 type III secretion system (T3SS). After assembly of a T3SS-linked pore in the vacuole membrane, bacteria sense the near-neutral pH of the host cell cytoplasm. This triggers the translocation of bacterial virulence proteins (effectors) into the host cell.
Approximately 30 different effectors are translocated by the SPI-2 T3SS. These have been implicated in several physiological activities, including the control of SCV positioning within the host cell, maintenance of vacuole membrane integrity, bacterial replication, interference with lysosome function and innate immune signaling. I will discuss our recent progress on an effector that suppresses the development of adaptive immunity, which is likely to contribute to the ability of Salmonella to persist in host tissues.
For more information here is a description of his work: http://www.imperial.ac.uk/people/d.holden
contact : Suzana Salcedo