Forum d’Infectiologie « spécialité Immunologie »: Pr. Ulrich KALINKE
Date / Heure
Date(s) - 04/07/2019
11 h 00 min - 12 h 00 min
salle des Thèses Chantal Rabourdin-Combes
Pr. Ulrich KALINKE (Helmholtz Centre for Infection Research Centre for Experimental and Clinical Infection Research Hanover – Germany): “ Virus defense at the brain border ”
Many viruses exploit the odorant system and enter the CNS via the olfactory bulb (OB). Upon intranasal vesicular stomatitis virus instillation, we show an accumulation of activated microglia and monocytes in the OB. Depletion of microglia during encephalitis results in enhanced virus spread and increased lethality. Activation, proliferation, and accumulation of microglia are regulated by type I IFN receptor signaling of neurons and astrocytes, but not of microglia. Morphological analysis of myeloid cells shows that type I IFN receptor signaling of neurons has a stronger impact on the activation of myeloid cells than of astrocytes. Thus, in the infected CNS, the cross talk among neurons, astrocytes, and microglia is critical for full microglia activation and protection from lethal encephalitis.
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