Séminaire CIRI: Anne Dejan
Date / Heure
Date(s) - 08/03/2017
11 h 00 min - 12 h 00 min
Amphi Pasteur, Tour CERVI
Anne Dejan ((Inserm UMR1043/CNRS5282, Toulouse).
Titre: » The Foxo3 / eomes axis controls CD4 T cell polarization »
The overarching objective of our team is to dissect the cellular and molecular mechanisms underlying susceptibility to immune-mediated disease with a particular focus on inflammatory diseases of the central nervous system.
We recently demonstrated that the transcription factor Foxo3 plays a key role in the physiopathology of neuroinflammation since Foxo3-deficiency is associated with a significant decrease in the severity of EAE. We also provided evidence that this decreased severity of EAE is the consequence of the inability of Foxo3-deficient CD4 T cells to differentiate into pathogenic T helper-1 cells producing IFN-g and GM-CSF. At the molecular level, we identified Eomes as a direct target gene for Foxo3 in CD4+ T cells and we have shown that lentiviral-based overexpression of Eomes in Foxo3-deficient CD4+ T cells restored both IFN-g and GM-CSF production. Thus, the Foxo3-Eomes pathway is central to achieve the complete specialized gene program required for pathogenic Th1 cell differentiation and development of neuroinflammation.
Invitée par Thierry.Walzer