Séminaire CIRI: Benoit MARTEYN.
Date / Heure
Date(s) - 05/12/2017
11 h 00 min - 12 h 00 min
Amphi Pasteur, Tour CERVI
Benoit MARTEYN (Institut Pasteur de Paris, Unité de Pathogénie Microbienne Moléculaire, Gustave Roussy Cancer Campus): « Oxygen interplay during Shigella infection »
Shigella is a pathogenic enterobacteria which is the causative agent of the bacillary dysentery or shigellosis. Until now, no vaccine against Shigella is commercialized. Tremendous efforts have been made to to better understand the modulation of Shigella virulence step in vivo. Shigella expresses three different secretion systems, T3SS, T5SS and T6SS, whom role is studied during the infectious process. In particular, we investigate to which extent oxygen is required for Shigella virulence activation (mediated by secretion systems), but also how the colonic mucosal oxygen level is modulated during Shigella invasion and its impact on the course of the infection.
Contact : Thomas Henry