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Date / Heure
Date(s) - 08/02/2017
11 h 00 min - 12 h 00 min

Amphi Pasteur, Tour CERVI

Cesar MUNOZ-FONTELA: (Institut d’Hambourg – ALLEMAGNE)

Title:“Immunology of hemorrhagic fever viruses in animal models and humans

Abstract: Viral hemorrhagic fevers are severe infections caused by RNA viruses from different families. Two of the
more prominent examples, Lassa fever and Ebola virus disease, have recently coincided in West Africa
causing thousands of human deaths. Despite the threat that these viral infections pose for global health,
very little is known about the basic pathophysiology mechanisms of Lassa and Ebola infection. The
scarcity of human data and the lack of immune competent animal models allowing endpoint experiments
are some of the problems associated to research with these virus. Here I will present data gathered in
my laboratory during the last five years on the physiology of the immune response against Lassa and
Ebola viruses in mice and humans. I will focus on the development of new immunocompetent animal
models and the differences between Ebola and Lassa infection. Additionally, I will discuss human data
highlighting the gaps between animal model and human immunology-based studies in the field during

contact : mathieu.mateo@pasteur.fr