Séminaire CIRI : Dr. Alessandra CARBONE
Date / Heure
Date(s) - 12/09/2019
10 h 00 min - 11 h 00 min
salle des Thèses Chantal Rabourdin-Combes
Dr. Alessandra CARBONE (Dpt of Computational and Quantitative Biology, Sorbonne Universty & CNRS – Paris) : “ Protein coevolution and the viral world ”
A fundamental question in computational biology is the extraction of evolutionary information from protein sequences. This information relates to protein-protein binding sites and the mechanical and allosteric properties of proteins. We will present a computational approach for co-evolution analysis and apply it to the reconstruction of viral genome protein networks. We will show how the interaction network of the hepatitis C virus genome proteins can be reconstructed at a residue / domain resolution and will briefly present recent experimental work demonstrating the fusion of HCV as a unique mechanism. This work provides a proof of concept for a broader exploration of viral protein-mediated processes and highlights coevolution as a valuable tool for guiding the design of viral inhibitors. In a second example, we will show how, a generalization of the method applied to the hepatitis B virus, provides important information on primary and secondary mutations in response to antiviral drugs.
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