Séminaire CIRI: Dr Anne LAVERGNE

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Date / Heure
Date(s) - 02/07/2019
23 h 00 min - 14 h 00 min

Amphi Pasteur, Tour CERVI

Dr Anne LAVERGNE (Laboratoire des Intéractions Virus-Hôtes, Institut Pasteur de la Guyane – Cayenne):  » Innate immune competency of two New World bat species  »

Bats are associated with several deadly emerging viruses such as rabies virus, SRAS, Ebola or Nipah. Although these viruses are often fatal in humans, they do not seem to cause any symptoms in the bats. One of the hypotheses to explain the « tolerance » of bats to infection is that they possess a particular innate immune system that allows them to quickly control viral infection. In order to characterize the innate immune competency in New World bats, several genes related to the interferon system such as Toll-like receptors, RIG-I-like receptors Interferon 1 and  as well as some IFN-stimulated genes (OAS-1, PKR, ADAR) were described in Desmodus rotundus and Carollia. perspicillata. In parallel, two immortalized cell lines have been established from the same two species. This allowed us to evaluate the efficacy of the bat pathogen recognition receptors and to follow induction of the IFN pathway in the bat cell lines upon stimulation using Poly(I:C) that confirm a robust
and functional IFN pathway.

contact : branka.horvat@inserm.fr