Séminaire CIRI: Dr. Elias HOBEIKA
Date / Heure
Date(s) - 24/01/2019
11 h 00 min - 12 h 00 min
Dr. Elias HOBEIKA (Institute of Immunology – Ulm University Hospital Ulm – RFA): “ B cell antigen receptor signaling in maintenance of mature as well as CLL-like B cells ”
Expression of a functional B cell antigen receptor (BCR) is essential for the maintenance and differentiation of B cells. It is thus not surprising that multiple B cell-derived malignancies critically depend on BCR-signaling in terms of their development and retention. Accordingly, in chronic lymphocytic leukemia (CLL), inhibition of signaling molecules downstream of the BCR, like the Bruton’s Tyrosine Kinase (BTK) by Ibrutinib, leads to the efficient eradication of the malignant cells. In the presented work, we investigate the importance of the BCR signaling for the maintenance of leukemic B cells derived from the EmTcl-1 mouse model for a CLL-like disease. We report that inactivation of either Igα or Igβ on the EmTcl-1-transgenic background results in a rapid demise of the CLL-like B cells thus demonstrating that BCR-expression and subsequently BCR-signaling are indispensable for the maintenance of CLL-like B cells in vivo. We are now investigating the signaling pathways, which may contribute to the rescue of the BCR-deficient CLL-like B cells from elimination.
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