Séminaire CIRI : Dr. Georg GASTEIGER
Date / Heure
Date(s) - 10/07/2019
14 h 30 min - 15 h 30 min
Amphi Pasteur, Tour CERVI
Dr Georg GASTEIGER (Julius-Maximiliams University of Würzburg ; Würzburg institute of systems immunology, RFA): “ Local players in immunity: differentiation and functions of tissue-resident lymphocytes ”
Local networks of tissue-resident lymphocytes are strategically positioned in diverse anatomical compartments, including epithelial barrier surfaces such as the skin, the lung and the gut, where they provide immune surveillance and front-line defense to microbial invasion. In addition to immediate immunological effector activities, tissue-resident lymphocytes interact locally with both hematopoietic and non-hematopoietic cells and contribute to physiologic mechanisms of tissue homeostasis, repair and barrier function. The recently discovered innate lymphoid cells (ILCs) and tissue-resident memory T (TRM) cells represent prototypic lymphocytes that differentiate into resident cells either “by default” during ontogeny, or that are induced in response to environmental challenges, respectively. The size, microanatomical localization and subset composition of the local pools of lymphocytes differs quite dramatically among different organs under physiologic conditions. Recent evidences suggest that these local lymphocyte networks are restructured during and play important roles in inflammatory diseases and cancer. Our aim is to understand the development and coordinated function of resident lymphocytes in specific tissue niches. We will discuss our recent work using single-cell mRNA sequencing to understand the differentiation of ILCs and TRMs during infection and tissue-repair in lung and skin.
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