Séminaire CIRI : Dr. Jane McKEATING

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Date / Heure
Date(s) - 10/10/2019
11 h 00 min - 12 h 00 min

Emplacement
Amphi Pasteur, Tour CERVI


Dr. Jane McKEATING (Nuffield Department of Medicine, University of Oxford – UK) : “ Circadian regulation of virus replication

Résumé:
All living organisms follow a circadian rhythm that coordinates physiological, behavioural and biochemical responses to the environment. Such daily variations include the risk of infection and it is now well recognised that host innate and adaptive immune responses are circadian regulated and influence susceptibility to infectious agents and response to vaccines. Understanding the selective advantage the circadian clock confers on viral fitness will provide fundamental insights into virus-host cell interactions.
Circadian signalling pathways are primarily controlled by the transcription activators BMAL1 and CLOCK. The nuclear hormone receptors REV-ERBα and REV-ERBβ are BMAL1-responsive clock components that regulate metabolic gene expression in a circadian and tissue-dependent manner. We recently reported that REV-ERB regulates hepatocellular susceptibility to dengue virus, hepatitis C virus and zika virus replication, highlighting REV-ERB as a new restriction factor for flaviviruses. https://www.ncbi.nlm.nih.gov/pubmed/30670689

contact : francois-loic.cosset@ens-lyon.fr

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