Séminaire CIRI: Dr. Jean-Philippe GIRARD
Date / Heure
Date(s) - 03/04/2018
11 h 00 min - 12 h 00 min
Amphi Pasteur, Tour CERVI
Dr. Jean-Philippe GIRARD (Directeur de l’Institut de Pharmacologie et de Biologie Structurale (IPBS )CNRS – Université de Toulouse): “ Interleukin-33 (IL-33) : an IL-1 family cytokine with crucial roles in innate immunity, inflammation and allergy ”.
Interleukin-33 (IL-33) is a nuclear cytokine from the IL-1 family abundantly expressed in epithelial barrier tissues and lymphoid organs, both during homeostasis and inflammation. It functions as an alarm signal (alarmin) released upon cell injury or tissue damage to alert immune cells expressing the ST2 receptor (IL-1RL1). The major targets of IL-33 in vivo are tissue-resident immune cells such as mast cells, group 2 innate lymphoid cells (ILC2s) and regulatory T cells (Tregs). Other cellular targets include T helper 2 (Th2) cells, eosinophils, basophils, dendritic cells, Th1 cells, CD8+ T cells, NK cells, iNKT cells, B cells, neutrophils and macrophages. IL-33 is thus emerging as a crucial immune modulator with pleiotropic activities in type-2, type-1 and regulatory immune responses, and important roles in allergic, fibrotic, infectious, and chronic inflammatory diseases. The critical function of IL-33/ST2 signaling in allergic inflammation is illustrated by the fact that the genes encoding IL-33 and ST2 are among the most highly replicated susceptibility loci for asthma. In this conference, Dr. Girard will highlight 15 years of discoveries on IL-33 protein, including its molecular characteristics, bioactive forms, cellular sources, mechanisms of release and regulation. Importantly, he will present recent data that provide a better understanding of the molecular mechanisms involved in the initiation of allergic type-2 inflammation.
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