Séminaire CIRI: Dr. Roméo RICCI
Date / Heure
Date(s) - 13/03/2018
11 h 00 min - 12 h 00 min
salle des Thèses Chantal Rabourdin-Combes
Dr. Roméo RICCI (Institut de génétique et de biologie moléculaire et cellulaire Illkirch-Graffenstaden): “ Endomembrane signaling and NLRP3 inflammasome activation ”
The inflammasome is a multiprotein complex that senses tissue damage and infectious agents to initiate immune responses. Distinct inflammasomes containing specific sensing molecules, including NLRP3, exist. We discovered that assembly of the NLRP3 inflammasome requires recruitment of NLRP3 to mitochondria-associated Endoplasmic Reticulum (ER) membranes (MAMs) adjacent to Golgi membranes. Compartmentalization of NLRP3 to MAMs is crucial for its self-oligomerization, while signaling from the Golgi is required to release NLRP3 from MAMs resulting in full assembly of the inflammasome. Our work thus provided unique insights into the spatially and temporally controlled mechanisms underlying NLRP3 inflammasome assembly.
contact : Bénédicte Py