Séminaire CIRI: Dr. Ron DISKIN
Date / Heure
Date(s) - 12/06/2019
11 h 00 min - 12 h 00 min
Amphi Pasteur, Tour CERVI
Dr. Ron DISKIN (Weizmann Institute of Science Department of Structural Biology – Rehovot, Israël), “ Cell entry and immune evasion mechanisms of Arenaviruses – from basic research to novel therapeutics ”
Viral hemorrhagic fevers are devastating human diseases that pose a significant risk to millions of people worldwide. Many of the viruses that cause hemorrhagic fevers are highly contagious and may hence cause outbreaks. The Arenaviridae family of viruses includes some notorious pathogens like the ‘Old World’ Lassa virus in Africa and a series of deadly ‘New World’ viruses in South America that cause hemorrhagic fevers in Brazil, Bolivia, Venezuela, and Argentina. In recent years we have been characterizing surface glycoproteins from various Arenaviruses to elucidate how these viruses locate their target cells and ultimately penetrate to them. For that, we mainly utilize structural and biochemical approaches that allow us to obtain molecular-level insights for the viral entry processes. During my talk, various molecular mechanisms that Lassa virus is utilizing to make its cell entry more efficient compared to other viruses from this family will be discussed. Also, a mechanism that helps Lassa virus to subvert host humoral immune response during infection will be presented alongside the implications of our findings to other Arenaviruses. In addition, I will address the molecular basis for selective use of TfR1 orthologs by ‘New World’ Arenaviruses and how we utilized this knowledge to develop a novel immunotherapeutic approach against these viruses.
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