Séminaire CIRI: Jean-Luc BATTINI
Date / Heure
Date(s) - 12/12/2017
11 h 30 min - 12 h 30 min
Salle sous/sol LR5, ENS-Lyon
Jean-Luc BATTINI (Institut de Recherche en infectiologie de Montpellier -IRIM- CNRS UMR 9004 – Université de Montpellier): « Role of retroviral receptors in phosphate homeostasis and calcification »
Phosphate is one of the key minerals in the body that participates in the synthesis of nucleic acids and membranes, bone and tooth mineralization, energy production (ATP) and signal transduction. At the same time, phosphate can be toxic when it exists in excess. Phosphate is present in blood, cerebrospinal fluid (CSF) and cells and its concentration is tightly regulated by phosphate transporters. Defect in phosphate transport may thus have severe clinical consequences. We are interested in a family of retroviral receptors that transport phosphate and that were recently associated to a familial brain calcification disease. Recent avances on the role of these retroviral receptors/phosphate transporters in phosphate homeostasis and sensing will be presented. Legati A., Giovannini D., …, Geschwind DH., Battini JL.*, Coppola G*. 2015. Mutations in XPR1 cause primary familial brain calcification associated with altered phosphate export. Nature Genetics 47: 579–581.
Giovannini D., Touhami J., Charnet P., Sitbon M., Battini JL. 2013. Inorganic phosphate export by the retrovirus receptor XPR1 in metazoans. 2013. Cell Reports 3: 1866-73.
Contact : François-Loïc Cosset