Séminaire CIRI: Jérome CAVAILLE.
Date / Heure
Date(s) - 06/02/2017
11 h 00 min - 12 h 00 min
salle des Thèses Chantal Rabourdin-Combes
Jérôme CAVAILLE (Université de Toulouse; UPS; Laboratoire de Biologie Moléculaire Eucaryote, Toulouse)
Title: “Biological functions of printed small regulatory RNAs”
Abstract: Box C/D containing small nucleolar RNAs (SNORDs) and microRNAs (miRNAs) are part of ribonucleoparticle complexes in which they serve as RNA guides to target other cellular RNAs via Watson-Crick base-pairing. Through the formation of perfect RNA duplexes, the vast majority of SNORDs direct site-specific 2’-0-methylation at selected nucleotides onto ribosomal RNAs while miRNAs function in post-transcriptional gene silencing, either by accelerating degradation and/or by inhibiting translation of the targeted mRNAs with which they associate through partial complementarities. Strikingly, some placental mammal-specific SNORDs and microRNA genes are subjected to genomic imprinting, a developmentally-regulated form of epigenetic regulation that causes mono-allelic expression in a parent-of-origin specific manner. Only about 100 imprinted genes have been documented in placental mammals, yet most of them play critical roles in pre- and post-natal growth as well as in metabolic adaptation and neurological pathways in
adulthood. Through the use of knockout mouse models, the rationale of our ongoing research is to explore the impact
of imprinted small noncoding RNA genes on the evolution, expression and function of mammalian genomes, including
in pathological contexts such as the Prader-Willi syndrome.
Contact : Emiliano Ricci