Séminaire CIRI: Patrick LEGEMBRE
Date / Heure
Date(s) - 24/01/2018
11 h 00 min - 12 h 00 min
Amphi Pasteur, Tour CERVI
Patrick LEGEMBRE (CLCC Eugene Marquis INSERM U1242-COSS, Rennes – France): “CD95/Fas, from a death receptor to an oncogene and a pro-inflammatory receptor: therapeutic prospectives”
CD95 (Fas/APO-1) is a transmembrane receptor that belongs to the tumor necrosis factor receptor (TNF-R) family. Its ligand, CD95L, is a transmembrane glycoprotein mainly expressed by activated T lymphocytes and NK cells. This membrane-bound ligand acts locally through cell-to-cell contact to kill infected and transformed cells. The extracellular domain of human CD95L can be cleaved by metalloproteases, releasing a soluble CD95L (s-CD95L) into the bloodstream. Unlike membrane-bound CD95L (m-CD95L), s-CD95L fails to trigger cell death but instead contributes to aggravating inflammation in chronic inflammatory disorders such as systemic lupus erythematosus (SLE) and cancers by inducing non-apoptotic signaling pathways including MAPK, NF-κB and PI3K. This lecture will focus on the CD95-mediated non-apoptotic signaling pathways and their role in lupus patients. Moreover, the therapeutic effect of original drugs targeting this signal will be discussed.
contact : Thierry Defrance