Séminaire CIRI: Pr. Endre KISS-TOTH
Date / Heure
Date(s) - 15/03/2018
11 h 00 min - 12 h 00 min
salle des Thèses Chantal Rabourdin-Combes
Pr. Endre KISS-TOTH (University of Sheffield, Medical School United Kingdom): “Regulatory mechanisms of macrophage function; from basic signalling to in vivo models of human disease”
Macrophages have always been seen as a key phagocytic cell type, central to innate immune responses. However, due to knowledge accumulated in recent years, it is now evident that their function is much more complex and macrophages are not only involved in fighting infections and healing tissue injury, they also play a key role in development of human disease, including chronic inflammatory syndromes, immune-metabolic diseases, such as cardiovascular disease and cancer.
The central scientific interest of our group is to understand regulatory mechanisms which underpin macrophage action in physiological as well as pathological processes. This seminar will summarise our discovery and characterisation of novel innate immune regulators of STING and MAPK/PI3K signalling pathways in macrophages, using a range of in vitro and transgenic models. Some of this work highlights the plasticity of tissue macrophages and demonstrates the importance of metabolic drivers in shaping macrophage function in vivo.
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