Séminaire CIRI: Pr. Heather MELICHAR

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Date / Heure
Date(s) - 14/09/2018
11 h 00 min - 12 h 00 min

Salle sous/sol LR5, ENS-Lyon

Pr. Heather MELICHAR (Département de Médecine, Université de Montréal): “ Self-reactive T cells : many shades of gray


T cells function to eliminate abnormal or infected cells. They distinguish, with incredible specificity, self- from foreign-peptides, and there are multiple regulatory layers in place to prevent the generation and activation of T cells that bind with high affinity to self-antigens. However, interactions between T cells and self-peptide are required for the development of functional T cells in the thymus, their survival in the periphery, and their expansion in lymphopenic environments. These low-affinity Interactions do not cause overt T cell activation, but are implicated in the establishment of functional heterogeneity within the T cell compartment. The goal of our lab is to understand how subtle differences in self-reactivity influence T cell development and function. We approach this problem from a cellular perspective, studying how T cells communicate with support cells in the thymic microenvironment throughout their development and how these interactions influence their function in the peripheral lymphoid organs.

contact : yann.leverrier@inserm.fr