Séminaire CIRI : Pr. Jonathan D. SCHERTZER
Date / Heure
Date(s) - 19/03/2019
11 h 00 min - 12 h 00 min
Amphi Pasteur, Tour CERVI
Pr. Jonathan D. SCHERTZER (McMaster University Biochemistry and Biomedical Sciences Hamilton, Ontario, Canada): “ Sensors of bugs and drugs alter metabolic danger in fat and muscle ”
Chronic inflammation coincides with obesity and contributes to metabolic diseases, including diabetes. The triggers of inflammation in metabolic diseases are ill-defined. The microbiota has been proposed as a mediator of obesity and trigger of host Inflammation. There are limited drugs to lower inflammation during metabolic disease. We describe a component of the microbiota or “postbiotic” that lowers fat tissue inflammation and blood glucose. Some current drugs may actually increase inflammation and glucose. Statins are widely prescribed, but can increase blood glucose and have myopathic side effects. We describe how statins promote inflammation and side-effects via a metabolic danger sensor.
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