séminaire: Dr. Elisa FANUNZA
Date / Heure
Date(s) - 11/06/2019
11 h 00 min
Amphi Pasteur, Tour CERVI
Dr. Elisa FANUNZA (Laboratory of Molecular Virology University of Cagliary, Italy): “ Flavonoid derivatives restore Interferon signaling pathway inhibited by Ebola virus VP24 ”
Ebola virus (EBOV) is highly pathogenic virus causing fatal hemorrhagic fever in humans. The 2013–2016 outbreak resulted in over 28000 infections with more than 11000 deaths and subsequent Ebola outbreak in Congo is still ongoing. Despite particular attention has been focused on the development of anti-EBOV agents, there is still no FDA-approved drug to fight the virus in case of any new epidemic. Considering the tight correlation between the high virulence and the suppression of the Interferon (IFN) system by EBOV, finding molecules targeting viral protein VP24, one of the main virulence determinants, is emerging as a promising novel anti-EBOV therapy approach. We performed a screening of different flavonoids with the aim to identify VP24 inhibitors and potential hits for drug development. Among the screened compounds, Quercetin was the most active compound, leading to an almost complete restoration of the IFN signaling cascade and thus representing a promising hit for further drug development.
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