Herpesvirus oncogènes

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Publications

2019

Viral oncogenesis and genomic instability: the centr(osom)al connection.
Teruel E, Gruffat H, Tommasino M, Journo C.
Virologie (Montrouge). 2019 Oct 1;23(5):16-31. doi: 10.1684/vir.2019.0793.

The interferon stimulated gene 20 protein (ISG20) is an innate defense antiviral factor that discriminates self versus non-self translation.
Wu N, Nguyen XN, Wang L, Appourchaux R, Zhang C, Panthu B, Gruffat H, Journo C, Alais S, Qin J, Zhang N, Tartour K, Catez F, Mahieux R, Ohlmann T, Liu M, Du B, Cimarelli A.
PLoS Pathog. 2019 Oct 10;15(10):e1008093. doi: 10.1371/journal.ppat.1008093. eCollection 2019 Oct.

Lyon, a critical place for performing Virology research.
Gerlier D, Gruffat H, Mahieux R.
Virologie (Montrouge). 2019 Mar 1;23(2):43-44. doi: 10.1684/vir.2019.0766. French. No abstract

Interplay between the epigenetic enzyme lysine (K)-specific demethylase 2B and Epstein-Barr virus infection.
Vargas-Ayala RC, Jay A, Manara F, Maroui MA, Hernandez-Vargas H, Diederichs A, Robitaille A, Sirand C, Ceraolo MG, Romero-Medina MC, Cros MP, Cuenin C, Durand G, Le Calvez-Kelm F, Mundo L, Leoncini L, Manet E, Herceg Z, Gruffat H*, Accardi R*. (* corresponding authors)
J Virol. 2019 Apr 17. pii: JVI.00273-19. doi: 10.1128/JVI.00273-19.

SRSF3: from mRNA decay to mRNA nuclear export. Epstein-Barr virus helps to make a choice.
Gruffat H, Mure F, Manet E.
Med Sci (Paris). 2019 Feb;35(2):103-105. doi: 10.1051/medsci/2019015. French.

2018

The splicing factor SRSF3 is functionally connected to the nuclear RNA exosome for intronless mRNA decay.
Mure F, Corbin A, Benbahouche NEH, Bertrand E, Manet E, Gruffat H.
Sci Rep. 2018 Aug 27;8(1):12901. doi: 10.1038/s41598-018-31078-1.

EBNA1: Oncogenic Activity, Immune Evasion and Biochemical Functions Provide Targets for Novel Therapeutic Strategies against Epstein-Barr Virus- Associated Cancers.
Wilson, J.B.; Manet, E.; Gruffat, H.; Busson, P.; Blondel, M.; Fahraeus, R.
Cancers 2018, 10, 109.

EBV/KSHV co-infection: an effective partnership.
Gruffat H, Manet E.
Med Sci (Paris). 2018 Jan;34(1):79-82. doi: 10.1051/medsci/20183401017.

Epstein-Barr virus protein EB2 stimulates translation initiation of mRNAs through direct interactions with both PABP and eIF4G.
Fabrice Mure, Baptiste Panthu, Isabelle Zanella-Cléon, Frédéric Delolme, Evelyne Manet, Théophile Ohlmann and Henri Gruffat.
J Virol. 2018 Jan 17;92(3). pii: e01917-17. doi: 10.1128/JVI.01917-17.

2017

Interference with the production of infectious viral particles and bimodal inhibition of replication are broadly conserved antiviral properties of IFITMs.
Tartour K, Nguyen XN, Appourchaux R, Assil S, Barateau V, Bloyet LM, Burlaud Gaillard J, Confort MP, Escudero-Perez B, Gruffat H, Hong SS, Moroso M, Reynard O, Reynard S, Decembre E, Ftaich N, Rossi A, Wu N, Arnaud F, Baize S, Dreux M, Gerlier D, Paranhos-Baccala G, Volchkov V, Roingeard P, Cimarelli A.
PLoS Pathog. 2017 Sep 28;13(9):e1006610. doi: 10.1371/journal.ppat.1006610

Viral driven epigenetic events alter the expression of cancer-related genes in Epstein-Barr-virus naturally infected Burkitt lymphoma cell lines.
Hernandez-Vargas H, Gruffat H, Cros MP, Diederichs A, Sirand C, Vargas-Ayala RC, Jay A, Durand G, Le Calvez-Kelm F, Herceg Z, Manet E, Wild CP, Tommasino M, Accardi R.
Sci Rep. 2017 Jul 19;7(1):5852. doi: 10.1038/s41598-017-05713-2.

Epstein-Barr virus nuclear antigen 1 interacts with regulator of chromosome condensation 1 dynamically throughout the cell cycle.
Deschamps T, Bazot Q, Leske DM, MacLeod R, Mompelat D, Tafforeau L, Lotteau V, Maréchal V, Baillie GS, Gruffat H, Wilson JB, Manet E.
J Gen Virol. 2017 Feb;98(2):251-265. doi: 10.1099/jgv.0.000681.

2016

Herpesvirus late gene expression: a viral-specific Pre-Initiation Complex is key.
Gruffat H, Marchione R and Manet E.
Front. Microbiol. doi: 10.3389/fmicb.2016.00869

2015

The mycotoxin aflatoxin B1 stimulates Epstein-Barr virus-induced B-cell transformation in in vitro and in vivo experimental models.
Accardi R, Gruffat H, Sirand C, Fusil F, Gheit T, Hernandez-Vargas H, Le Calvez-Kelm F, Traverse-Glehen A, Cosset FL, Manet E, Wild CP, Tommasino M.
Carcinogenesis. 2015 Sep 30. pii: bgv142.

In vitro translation of mRNAs that are in their native ribonucleoprotein complex (mRNPs).
Panthu B, Mure F, Gruffat H, Ohlmann T.
Biochem J. 2015 Sep 8. pii: BJ20150772.

2014

Epstein-barr virus late gene transcription depends on the assembly of a virus-specific preinitiation complex.
Aubry V, Mure F, Mariamé B, Deschamps T, Wyrwicz LS, Manet E, Gruffat H.
J Virol. 2014 Nov 1;88(21):12825-38. doi: 10.1128/JVI.02139-14.

TLR9 Transcriptional Regulation in Response to Double-Stranded DNA Viruses.
Zannetti C, Parroche P, Panaye M, Roblot G, Gruffat H, Manet E, Debaud AL, Plumas J, Vey N, Caux C, Bendriss-Vermare N, Hasan UA.
J Immunol. 2014 Oct 1;193(7):3398-408. doi: 10.4049/jimmunol.1400249.

Epstein-Barr virus nuclear antigen 3A protein regulates CDKN2B transcription via interaction with MIZ-1.
Bazot Q, Deschamps T, Tafforeau L, Siouda M, Leblanc P, Harth-Hertle ML, Rabourdin-Combe C, Lotteau V, Kempkes B, Tommasino M, Gruffat H, Manet E.
Nucleic Acids Res. 2014 Nov 1;42(15):9700-16. doi: 10.1093/nar/gku697.

Epstein-Barr Virus Down-Regulates Tumor Suppressor DOK1 Expression.
Siouda M, Frecha C, Accardi R, Yue J, Cuenin C, Gruffat H, Manet E, Herceg Z, Sylla BS, Tommasino M.
PLoS Pathog. 2014 May 8;10(5):e1004125. doi: 10.1371/journal.ppat.1004125.

Mutations in the H, F, or M Proteins Can Facilitate Resistance of Measles Virus to Neutralizing Human Anti-MV Sera.
Kweder H, Ainouze M, Cosby SL, Muller CP, Lévy C, Verhoeyen E, Cosset FL, Manet E, Buckland R.
Adv Virol. 2014;2014:205617. doi: 10.1155/2014/205617.

2013

Epstein – Barr virus transforming protein LMP-1 alters B cells gene expression by promoting accumulation of the oncoprotein ΔNp73α.
Accardi R, Fathallah I, Gruffat H, Mariggiò G, Le Calvez-Kelm F, Voegele C, Bartosch B, Hernandez-Vargas H, McKay J, Sylla BS, Manet E, Tommasino M.
PLoS Pathog. 2013 Mar;9(3):e1003186. doi: 10.1371/journal.ppat.1003186.

Drosophila Yemanuclein and HIRA cooperate for de novo assembly of H3.3-containing nucleosomes in the male pronucleus.
Orsi GA, Algazeery A, Meyer RE, Capri M, Sapey-Triomphe LM, Horard B, Gruffat H, Couble P, Aït-Ahmed O, Loppin B.
PLoS Genet. 2013;9(2):e1003285. doi: 10.1371/journal.pgen.1003285.

Interaction of Ubinuclein-1, a nuclear and adhesion junction protein, with the 14-3-3 epsilon protein in epithelial cells: implication of the PKA pathway.
Conti A, Sueur C, Lupo J, Brazzolotto X, Burmeister WP, Manet E, Gruffat H, Morand P, Boyer V.
Eur J Cell Biol. 2013 Mar;92(3):105-11. doi: 10.1016/j.ejcb.2012.12.001.

2012

Epstein-Barr virus protein EB2 stimulates cytoplasmic mRNA accumulation by counteracting the deleterious effects of SRp20 on viral mRNAs.
Juillard F, Bazot Q, Mure F, Tafforeau L, Macri C, Rabourdin-Combe C, Lotteau V, Manet E, Gruffat H.
Nucleic Acids Res. 2012 Aug;40(14):6834-49. doi: 10.1093/nar/gks319.

The Epstein-Barr virus BcRF1 gene product is a TBP-like protein with an essential role in late gene expression.
Gruffat H, Kadjouf F, Mariamé B, Manet E.
J Virol. 2012 Jun;86(11):6023-32. doi: 10.1128/JVI.00159-12.

Identification of new interacting partners of the shuttling protein ubinuclein (Ubn-1).
Lupo J, Conti A, Sueur C, Coly PA, Couté Y, Hunziker W, Burmeister WP, Germi R, Manet E, Gruffat H, Morand P, Boyer V.
Exp Cell Res. 2012 Mar 10;318(5):509-20. doi: 10.1016/j.yexcr.2011.12.020.

Functional mechanisms of the cellular prion protein (PrP(C)) associated anti-HIV-1 properties.
Alais S, Soto-Rifo R, Balter V, Gruffat H, Manet E, Schaeffer L, Darlix JL, Cimarelli A, Raposo G, Ohlmann T, Leblanc P.
Cell Mol Life Sci. 2012 Apr;69(8):1331-52. doi: 10.1007/s00018-011-0879-z.

2011

Homozygous deletion of EPB41 genuine AUG-containing exons results in mRNA splicing defects, NMD activation and protein 4.1R complete deficiency in hereditary elliptocytosis.
Baklouti F, Morinière M, Haj-Khélil A, Fénéant-Thibault M, Gruffat H, Couté Y, Ninot A, Guitton C, Delaunay J.
Blood Cells Mol Dis. 2011 Oct 15;47(3):158-65. doi: 10.1016/j.bcmd.2011.07.001.

The nuclear and adherent junction complex component protein ubinuclein negatively regulates the productive cycle of Epstein-Barr virus in epithelial cells.
Gruffat H, Lupo J, Morand P, Boyer V, Manet E.
J Virol. 2011 Jan;85(2):784-94. doi: 10.1128/JVI.01397-10.

2010

EBV latent membrane protein 1 is a negative regulator of TLR9.
Fathallah I, Parroche P, Gruffat H, Zannetti C, Johansson H, Yue J, Manet E, Tommasino M, Sylla BS, Hasan UA.
J Immunol. 2010 Dec 1;185(11):6439-47. doi: 10.4049/jimmunol.0903459.

2009

Varicella-zoster virus IE4 protein interacts with SR proteins and exports mRNAs through the TAP/NXF1 pathway.
Ote I, Lebrun M, Vandevenne P, Bontems S, Medina-Palazon C, Manet E, Piette J, Sadzot-Delvaux C.
PLoS One. 2009 Nov 18;4(11):e7882. doi: 10.1371/journal.pone.0007882.

Epstein-Barr virus protein EB2 contains an N-terminal transferable nuclear export signal that promotes nucleocytoplasmic export by directly binding TAP/NXF1.
Juillard F, Hiriart E, Sergeant N, Vingtdeux-Didier V, Drobecq H, Sergeant A, Manet E, Gruffat H.
J Virol. 2009 Dec;83(24):12759-68. doi: 10.1128/JVI.01276-09.

Translation of intronless RNAs is strongly stimulated by the Epstein-Barr virus mRNA export factor EB2.
Ricci EP, Mure F, Gruffat H, Decimo D, Medina-Palazon C, Ohlmann T, Manet E.
Nucleic Acids Res. 2009 Aug;37(15):4932-43. doi: 10.1093/nar/gkp497.

Methylation-dependent binding of the epstein-barr virus BZLF1 protein to viral promoters.
Dickerson SJ, Xing Y, Robinson AR, Seaman WT, Gruffat H, Kenney SC.
PLoS Pathog. 2009 Mar;5(3):e1000356. doi: 10.1371/journal.ppat.1000356.

Characterization of the ubinuclein protein as a new member of the nuclear and adhesion complex components (NACos).
Aho S, Lupo J, Coly PA, Sabine A, Castellazzi M, Morand P, Sergeant A, Manet E, Boyer V, Gruffat H.
Biol Cell. 2009 Jun;101(6):319-34. doi: 10.1042/BC20080072.

2008

The Epstein-Barr virus (EBV) protein EB is an mRNA export factor essential for virus production.
Sergeant A, Gruffat H, Manet E.
Front Biosci. 2008 May 1;13:3798-813.

Overexpression of MBNL1 fetal isoforms and modified splicing of Tau in the DM1 brain: two individual consequences of CUG trinucleotide repeats.
Dhaenens CM, Schraen-Maschke S, Tran H, Vingtdeux V, Ghanem D, Leroy O, Delplanque J, Vanbrussel E, Delacourte A, Vermersch P, Maurage CA, Gruffat H, Sergeant A, Mahadevan MS, Ishiura S, Buée L, Cooper TA, Caillet-Boudin ML, Charlet-Berguerand N, Sablonnière B, Sergeant N.
Exp Neurol. 2008 Apr;210(2):467-78. doi: 10.1016/j.expneurol.2007.11.020.