Immunobiologie des infections virales

Publications

Regulation of measles virus gene expression by P protein coiled-coil properties.  Bloyet, L.M. Schramm, A., Lazert, C., Raynal B., Hologn M., Walker O., Longhi S., and Gerlier D. Sci. Adv. 5, eaaw3702 (2019), doi: 10.1126/sciadv.aaw3702.

Type I Interferon receptor signaling drives selective permissiveness of astrocytes and microglia to measles virus during brain infection. Welsch J., Charvet B., Dussurgey S., Allatif O., Aurine N., Horvat B., Gerlier D., and Mathieu C. J. Virol. 2019, 2019 Apr 24. pii: JVI.00618-19. doi: 10.1128/JVI.00618-19

Measles virus bearing MIBE-derived fusion protein is pathogenic after infection via the respiratory route. Mathieu C., Ferren M., Jurgens E., Dumont C., Rybkina K., Harder O., Stelitano D., Ladeddu S, Sanna G., Schwartz D., Biswas S., Hardie D., Hashiguchi T., Moscona A., Horvat B., Niewiesk S. and Porotto M. J. Virol. 93(8) : 01862-18, 2019 doi: 10.1128/JVI.01862-1

Fusion inhibitory lipopeptides engineered for prophylaxis of Nipah virus in primates.  Mathieu C., Porotto M., Figueira T., Horvat B, Moscona A. J. Infect. Dises. 218(2): 218-227, 2018, doi: 10.1093/infdis/jiy152.

Induction of proinflammatory multiple sclerosis-associated retrovirus envelope protein by human herpesvirus-6A and CD46 receptor engagement. Charvet B., Reynaud J.M., Gourru-Lesimple G., Perron H., Marche P.N. and Horvat B. Front. Immunol., 9:2803, 1-14, 2018. doi: 10.3389/fimmu.2018.02803

HHV-6 Fondation newsletter

Analysis of a subacute sclerosing panencephalitis (SSPE) Genotype B3 virus from the 2009/10 South African measles epidemic shows hyperfusogenic F proteins contribute to measles virus infection in the brain. Angius F., Smuts H., Rybkina K., Stelitano D., Eley B., Wilmshurst J., Ferren M., Lalande A., Mathieu C., Moscona A., Horvat B., Hashiguchi T., Porotto M., and Hardie D.  J. Virol. in press, 2018. doi: 10.1128/JVI.01700-18

An ultraweak interaction in the intrinsically disordered replication machinery is essential for measles virus function. Milles S, Jensen MR, Lazert C, Guseva S, Ivashchenko S, Communie G, Maurin D, Gerlier D, Ruigrok RWH, Blackledge M.  Sci Adv. 2018, Aug 22;4(8),:eaat7778. doi: 10.1126/sciadv.aat7778. eCollection 2018 Aug

Organotypic brain cultures: a framework for studying CNS infection by neurotropic viruses and screening antiviral drugs. Welsch C.J., Lionnet C., TerzianC., Horvat B., Gerlier D., and Mathieu C. Bio-protocol 7(22): e2605, 2017, doi: 10.21769/BioProtoc.2605.

Broad spectrum antiviral activity for paramyxoviruses is modulated by biophysical properties of fusion inhibitory peptides. Mathieu C., Augusto M.T., Niewiesk S., Horvat B., Palermo L.M., Sanna G., Huey D., Castanho M.A.R.B., Porotto M., Santos N.C., Moscona A. Scient. Rep., 7:43610, 2017. doi:10.1038/srep43610

Measles virus infection of human keratinocytes: Possible link between measles and atopic. Gourru-Lesimple G., Mathieu C., Thevenet T., Guillaume-Vasselin V., Jégou J.F., Boer C.G., TomczakK., Bloyet L.M., Giraud C., Grande S., Goujon C., Cornu C. and Horvat B. Dermatol. Science, Feb 10, 2017, doi: 10.1016/j.jdermsci.2017.01.015

INSERM actualité

In vivo efficacy of measles virus fusion protein-derived peptides is modulated by properties of self-assembly and membrane residence. Figueira T.N., Palermo L.M., Veiga A.S., Huey D., Alabi C.A., Santos N.C., Welsch J.C., Mathieu C., Horvat B., Niewiesk S., Moscona A., Castanho M.A.R.B. and Porotto M. J. Virol. 91(1): e0554-16 2017. PMID: 27733647

Understanding the interaction between henipaviruses and their natural host, fruit bats: paving the way towards control of highly lethal infection in humans. Enchery F., Horvat 2017 Internat. Rev. Immunol. Jan 6:1-14. doi: 10.1080/08830185.2016.1255883.

Modulation of Re-initiation of Measles Virus Transcription at Intergenic Regions by PXD to NTAIL Binding Strength.
Bloyet LM, Brunel J, Dosnon M, Hamon V, Erales J, Gruet A, Lazert C, Bignon C, Roche P, Longhi S, Gerlier D.
PLoS Pathog. 2016 Dec 9;12(12):e1006058. doi: 10.1371/journal.ppat.1006058.

Protection from Hendra virus infection with Canarypox recombinant vaccine.
Guillaume-Vasselin V., Lemaitre L., Dhondt K.P., Tedeschi L, Poulard A., Charreyre C. and Horvat B.
Nature pj Vaccines, 1: 16003, 2016, doi:10.1038/npjvaccines.2016.3

Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5.
Uchikawa E, Lethier M, Malet H, Brunel J, Gerlier D, Cusack S.
Mol Cell 62, 586-602, 2016, doi: 10.1016/j.molcel.2016.04.021.

Requirement of HSP90 chaperoning in addition to phosphoprotein for folding but not for supporting enzymatic activities of measles and Nipah virus L polymerases.
Bloyet LM, Welsch J, Enchery F, Mathieu C, de Breyne S, Horvat B, Grigorov B, Gerlier D.
J Virol. 90(15):6642-56, 2016. doi: 10.1128/JVI.00602-16

Intradermal immunisation using the TLR3-ligand Poly (I:C) as adjuvant induces mucosal antibody responses and protects against genital HSV-2 infection. Bardel E., Doucet-Ladeveze R., Mathieu C., Harandi A.M., Dubois D. and Kaiserlian D. Nature pj Vaccines, 1: 16010, 2016. doi:10.1038/npjvaccines.2016.10

Latency Entry of Herpes Simplex Virus 1 Is Determined by the Interaction of Its Genome with the Nuclear Environment. Maroui MA, Callé A, Cohen C, Streichenberger N, Texier P, Takissian J, Rousseau A, Poccardi N, Welsch J, Corpet A, Schaeffer L, Labetoulle M, Lomonte P. PLoS Pathog. 2016 Sep 12;12(9):e1005834

Fuzzy regions in an intrinsically disordered protein impair protein-protein interactions.
Gruet A, Dosnon M, Blocquel D, Brunel J, Gerlier D, Das RK, Bonetti D, Gianni S, Fuxreiter M, Longhi S, Bignon C.
FEBS J.  283(4):576-94, 2016. doi: 10.1111/febs.13631

Heparan Sulfate-dependent enhancement of Henipavirus infection.
Mathieu C., Dhondt K.P., Châlons M., Mély S., Raoul H., Negre D., Cosset F.L., Gerlier D., Vivès R.R., and Horvat B.
mBio, 6(2): e02427-14, 2015. doi: 10.1128/mBio.02427-14

Measles virus hemagglutinin triggers intracellular signaling in CD150-expressing dendritic cells and inhibits immune response.
Romanets-Korbut O., Kovalevska L., Seya T., Sidorenko S.P.,  Horvat B.
Cell & Mol Immunol. 13:828-838, 2016. doi: 10.1038/cmi.2015.55

Kinetic discrimination of self/non-self RNA by the ATPase activity of RIG-I and MDA5.
Louber J, Brunel J, Uchikawa E, Cusack S, Gerlier D.
BMC Biol. 28;13:54, 2015. doi: 10.1186/s12915-015-0166-9

Expression of CD150 in tumors of the central nervous system: identification of a novel isoform.
Romanets-Korbut O., Najakshin A.M., Yurchenko M., Malysheva T.A., Kovalevska L., Shlapatska L.M., Zozulya Y.A., Taranin A.V.,  Horvat B., Sidorenko S.P.
Plos One, 10(2):e0118302, 2015. doi: 10.1371/journal.pone.0118302

Prevention of Measles infection by intranasal delivery of fusion inhibitory peptides.
Mathieu C., Huey D., Jurgens E., Welsch J.C., DeVito I., Talekar A., Horvat B., Niewiesk S., Moscona A., and Porotto M.
J. Virol. 89(2):1143-1155, 2015. doi: 10.1128/JVI.02417-14

Suppression of Smad-1 mRNA expression level by Smad-2 likely control dichotomy of NF-κB and Smads mediated activation.
Slade N., Zorić A., Horvat B., Vukšić M., Kostović I., Poljak L.
Immunobiology. 220(1): 48-53, 2015. doi: 10.1016/j.imbio.2014.09.003

Measles fusion machinery is dysregulated in neuropathogenic variants,
JurgensE.M., Mathieu C., Palermo L.M., Hardie D., Horvat B., Moscona A.,and Porotto M.
mBio, 2015 Feb 10;6(1). pii: e02528-14. doi: 10.1128/mBio.02528-14

Henipavirus pathogenesis and anti-viral approaches.
Mathieu C. & Horvat B.
Expert Rev Anti Infect Ther 29:1-12, doi: 10.1586/14787210.2015.1001838., 2015

Measles Virus: Identification in the M Protein Primary Sequence of a Potential Molecular Marker for Subacute Sclerosing Panencephalitis.
Kweder, H., Ainouze, M., Brunel, J., Gerlier, D., Manet, E., and Buckland, R. (2015).
Adv Virol 2015, 2015:769837. doi: 10.1155/2015/769837

RIG-I self-oligomerization is either dispensable or very transient for signal transduction.
Louber, J., Kowalinski, E., Bloyet, L-M., Brunel, J., Cusack, S., Gerlier, D.
PLoS One, 2014, 26;9(9):e108770. doi: 10.1371/journal.pone.0108770.

Sequence of events in measles virus replication: role of phosphoprotein-nucleocapsid interactions.
Brunel, J. Chopy, D.,Dosnon, M. Bloyet, L-M. Devaux, P., Urzua, E., Cattaneo, R., Longhi, S. Gerlier, D.
J. Virol. 2014,  88(18):10851-63. doi: 10.1128/JVI.00664-14.

Human Herpesvirus 6A infection in CD46 transgenic mice: viral prevalence in the brain and increased production of proinflammatory cytokines via TLR9.
Reynaud J., Jégou J.F., Welsch J., Horvat. B.
J. Virol. 2014, 88 (10): 5421-5436, 2014. doi: 10.1128/JVI.03763-13.

Recent developments in animal models for human herpesvirus 6A and 6B.
Horvat B., Berges B.K., Lusso P.
Curr. Opin. Virol. 2014, 9 :97-103, 2014. doi: 10.1016/j.coviro.2014.09.012

Fatal measles virus infection prevented by brain-penetrant fusion inhibitors.
Welsch JC, Talekar A, Mathieu C, Pessi A, Moscona A, Horvat B, Porotto M.
J Virol. 2013 Dec;87(24):13785-94. doi: 10.1128/JVI.02436-13.

Animal models for human herpesvirus 6 infection.
Reynaud JM, Horvat B.
Front Microbiol. 2013 Jul 4;4:174. doi: 10.3389/fmicb.2013.00174.

Dissecting Partner Recognition by an Intrinsically Disordered Protein Using Descriptive Random Mutagenesis.
Gruet A, Dosnon M, Vassena A, Lombard V, Gerlier D, Bignon C, Longhi S.
J Mol Biol. 2013 Jun 25. doi:pii: S0022-2836(13)00405-1. 10.1016/j.jmb.2013.06.025.

The V protein of Tioman virus is incapable of blocking type I interferon signaling in human cells.
Caignard G, Lucas-Hourani M, Dhondt KP, Labernardière JL, Petit T, Jacob Y, Horvat B, Tangy F, Vidalain PO.
PLoS One. 2013;8(1):e53881. doi: 10.1371/journal.pone.0053881.

Protection against henipavirus infection by use of recombinant adeno-associated virus-vector vaccines.
Ploquin A, Szécsi J, Mathieu C, Guillaume V, Barateau V, Ong KC, Wong KT, Cosset FL, Horvat B, Salvetti A.
J Infect Dis. 2013 Feb 1;207(3):469-78. doi: 10.1093/infdis/jis699.

Type I interferon signaling protects mice from lethal henipavirus infection.
Dhondt KP, Mathieu C, Chalons M, Reynaud JM, Vallve A, Raoul H, Horvat B.
J Infect Dis. 2013 Jan 1;207(1):142-51. doi: 10.1093/infdis/jis653

Mechanism for active membrane fusion triggering by morbillivirus attachment protein.
Ader N, Brindley M, Avila M, Örvell C, Horvat B, Hiltensperger G, Schneider-Schaulies J, Vandevelde M, Zurbriggen A, Plemper RK, Plattet P.
J Virol. 2013 Jan;87(1):314-26. doi: 10.1128/JVI.01826-12.

Nonstructural Nipah virus C protein regulates both the early host proinflammatory response and viral virulence.
Mathieu C, Guillaume V, Volchkova VA, Pohl C, Jacquot F, Looi RY, Wong KT, Legras-Lachuer C, Volchkov VE, Lachuer J, Horvat B.
J Virol. 2012 Oct;86(19):10766-75. doi: 10.1128/JVI.01203-12.

A general strategy to endow natural fusion-protein-derived peptides with potent antiviral activity.
Pessi A, Langella A, Capitò E, Ghezzi S, Vicenzi E, Poli G, Ketas T, Mathieu C, Cortese R, Horvat B, Moscona A, Porotto M.
PLoS One. 2012;7(5):e36833. doi: 10.1371/journal.pone.0036833.

Emerging zoonotic viruses: new lessons on receptor and entry mechanisms.
Gerlier D.
Curr Opin Virol. 2011 Jul;1(1):27-34. doi: 10.1016/j.coviro.2011.05.014.

Rapid screening for entry inhibitors of highly pathogenic viruses under low-level biocontainment.
Talekar A, Pessi A, Glickman F, Sengupta U, Briese T, Whitt MA, Mathieu C, Horvat B, Moscona A, Porotto M.
PLoS One. 2012;7(3):e30538. doi: 10.1371/journal.pone.0030538.

Lethal Nipah virus infection induces rapid overexpression of CXCL10.
Mathieu C, Guillaume V, Sabine A, Ong KC, Wong KT, Legras-Lachuer C, Horvat B.
PLoS One. 2012;7(2):e32157. doi: 10.1371/journal.pone.0032157.

[RIG-I: a viral RNA detector molecular switch].
Kowalinski E, Louber J, Gerlier D, Cusack S.
Med Sci (Paris). 2012 Feb;28(2):136-8. doi: 10.1051/medsci/2012282006.

Plasticity in structural and functional interactions between the phosphoprotein and nucleoprotein of measles virus.
Shu Y, Habchi J, Costanzo S, Padilla A, Brunel J, Gerlier D, Oglesbee M, Longhi S.
J Biol Chem. 2012 Apr 6;287(15):11951-67. doi: 10.1074/jbc.M111.333088.

Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA.
Kowalinski E, Lunardi T, McCarthy AA, Louber J, Brunel J, Grigorov B, Gerlier D, Cusack S.
Cell. 2011 Oct 14;147(2):423-35. doi: 10.1016/j.cell.2011.09.039.

Virus-driven conditional expression of an interferon antagonist as a tool to circumvent host restriction.
Gerlier D.
Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17239-40. doi: 10.1073/pnas.1114431108.

Rapid titration of measles and other viruses: optimization with determination of replication cycle length.
Grigorov B, Rabilloud J, Lawrence P, Gerlier D.
PLoS One. 2011;6(9):e24135. doi: 10.1371/journal.pone.0024135.

Interplay between innate immunity and negative-strand RNA viruses: towards a rational model.
Gerlier D, Lyles DS.
Microbiol Mol Biol Rev. 2011 Sep;75(3):468-90, second page of table of contents. doi: 10.1128/MMBR.00007-11.

Molecular characterization of measles virus strains causing subacute sclerosing panencephalitis in France in 1977 and 2007.
Moulin E, Beal V, Jeantet D, Horvat B, Wild TF, Waku-Kouomou D.
J Med Virol. 2011 Sep;83(9):1614-23. doi: 10.1002/jmv.22152.

Nipah virus uses leukocytes for efficient dissemination within a host.
Mathieu C, Pohl C, Szecsi J, Trajkovic-Bodennec S, Devergnas S, Raoul H, Cosset FL, Gerlier D, Wild TF, Horvat B.
J Virol. 2011 Aug;85(15):7863-71. doi: 10.1128/JVI.00549-11.

Cellular receptors, differentiation and endocytosis requirements are key factors for type I IFN response by human epithelial, conventional and plasmacytoid dendritic infected cells by measles virus.
Duhen T, Herschke F, Azocar O, Druelle J, Plumet S, Delprat C, Schicklin S, Wild TF, Rabourdin-Combe C, Gerlier D, Valentin H.
Virus Res. 2010 Sep;152(1-2):115-25. doi: 10.1016/j.virusres.2010.06.013.

Co-circulation of multiple measles virus genotypes during an epidemic in France in 2008.
Waku-Kouomou D, Freymuth F, du Châtelet IP, Wild TF, Horvat B.
J Med Virol. 2010 May;82(6):1033-43. doi: 10.1002/jmv.21766.

Experimental infection of squirrel monkeys with nipah virus.
Marianneau P, Guillaume V, Wong T, Badmanathan M, Looi RY, Murri S, Loth P, Tordo N, Wild F, Horvat B, Contamin H.
Emerg Infect Dis. 2010 Mar;16(3):507-10. doi: 10.3201/eid1603.091346.

PolyI:C plus IL-2 or IL-12 induce IFN-gamma production by human NK cells via autocrine IFN-beta.
Duluc D, Tan F, Scotet M, Blanchard S, Frémaux I, Garo E, Horvat B, Eid P, Delneste Y, Jeannin P.
Eur J Immunol. 2009 Oct;39(10):2877-84. doi: 10.1002/eji.200838610.

iNKT cell development is orchestrated by different branches of TGF-beta signaling.
Doisne JM, Bartholin L, Yan KP, Garcia CN, Duarte N, Le Luduec JB, Vincent D, Cyprian F, Horvat B, Martel S, Rimokh R, Losson R, Benlagha K, Marie JC.
J Exp Med. 2009 Jun 8;206(6):1365-78. doi: 10.1084/jem.20090127.

The interaction between the measles virus nucleoprotein and the Interferon Regulator Factor 3 relies on a specific cellular environment.
Colombo M, Bourhis JM, Chamontin C, Soriano C, Villet S, Costanzo S, Couturier M, Belle V, Fournel A, Darbon H, Gerlier D, Longhi S.
Virol J. 2009 May 15;6:59. doi: 10.1186/1743-422X-6-59.

Acute Hendra virus infection: Analysis of the pathogenesis and passive antibody protection in the hamster model.
Guillaume V, Wong KT, Looi RY, Georges-Courbot MC, Barrot L, Buckland R, Wild TF, Horvat B.
Virology. 2009 May 10;387(2):459-65. doi: 10.1016/j.virol.2009.03.001.

Interplay between virus-specific effector response and Foxp3 regulatory T cells in measles virus immunopathogenesis.
Sellin CI, Jégou JF, Renneson J, Druelle J, Wild TF, Marie JC, Horvat B.
PLoS One. 2009;4(3):e4948. doi: 10.1371/journal.pone.0004948.

Measles virus interaction with host cells and impact on innate immunity.
Gerlier D, Valentin H.
Curr Top Microbiol Immunol. 2009;329:163-91.

Generation of mice with conditionally activated transforming growth factor beta signaling through the TbetaRI/ALK5 receptor.
Bartholin L, Cyprian FS, Vincent D, Garcia CN, Martel S, Horvat B, Berthet C, Goddard-Léon S, Treilleux I, Rimokh R, Marie JC.
Genesis. 2008 Dec;46(12):724-31. doi: 10.1002/dvg.20425.

Human C3 deficiency associated with impairments in dendritic cell differentiation, memory B cells, and regulatory T cells.
Ghannam A, Pernollet M, Fauquert JL, Monnier N, Ponard D, Villiers MB, Péguet-Navarro J, Tridon A, Lunardi J, Gerlier D, Drouet C.
J Immunol. 2008 Oct 1;181(7):5158-66.

Refined study of the interaction between HIV-1 p6 late domain and ALIX.
Lazert C, Chazal N, Briant L, Gerlier D, Cortay JC.
Retrovirology. 2008 May 13;5:39. doi: 10.1186/1742-4690-5-39.

High-density rafts preferentially host the complement activator measles virus F glycoprotein but not the regulators of complement activation.
Ghannam A, Hammache D, Matias C, Louwagie M, Garin J, Gerlier D.
Mol Immunol. 2008 Jun;45(11):3036-44. doi: 10.1016/j.molimm.2008.03.013.

Wild type measles virus attenuation independent of type I IFN.
Druelle J, Sellin CI, Waku-Kouomou D, Horvat B, Wild FT.
Virol J. 2008 Feb 3;5:22. doi: 10.1186/1743-422X-5-22

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Publications

Regulation of measles virus gene expression by P protein coiled-coil properties.  Bloyet, L.M. Schramm, A., Lazert, C., Raynal B., Hologn M., Walker O., Longhi S., and Gerlier D. Sci. Adv. 5, eaaw3702 (2019), doi: 10.1126/sciadv.aaw3702.

Type I Interferon receptor signaling drives selective permissiveness of astrocytes and microglia to measles virus during brain infection. Welsch J., Charvet B., Dussurgey S., Allatif O., Aurine N., Horvat B., Gerlier D., and Mathieu C. J. Virol. 2019, 2019 Apr 24. pii: JVI.00618-19. doi: 10.1128/JVI.00618-19

Measles virus bearing MIBE-derived fusion protein is pathogenic after infection via the respiratory route. Mathieu C., Ferren M., Jurgens E., Dumont C., Rybkina K., Harder O., Stelitano D., Ladeddu S, Sanna G., Schwartz D., Biswas S., Hardie D., Hashiguchi T., Moscona A., Horvat B., Niewiesk S. and Porotto M. J. Virol. 93(8) : 01862-18, 2019 doi: 10.1128/JVI.01862-1

Fusion inhibitory lipopeptides engineered for prophylaxis of Nipah virus in primates.  Mathieu C., Porotto M., Figueira T., Horvat B, Moscona A. J. Infect. Dises. 218(2): 218-227, 2018, doi: 10.1093/infdis/jiy152.

Induction of proinflammatory multiple sclerosis-associated retrovirus envelope protein by human herpesvirus-6A and CD46 receptor engagement. Charvet B., Reynaud J.M., Gourru-Lesimple G., Perron H., Marche P.N. and Horvat B. Front. Immunol., 9:2803, 1-14, 2018. doi: 10.3389/fimmu.2018.02803

HHV-6 Fondation newsletter

Analysis of a subacute sclerosing panencephalitis (SSPE) Genotype B3 virus from the 2009/10 South African measles epidemic shows hyperfusogenic F proteins contribute to measles virus infection in the brain. Angius F., Smuts H., Rybkina K., Stelitano D., Eley B., Wilmshurst J., Ferren M., Lalande A., Mathieu C., Moscona A., Horvat B., Hashiguchi T., Porotto M., and Hardie D.  J. Virol. in press, 2018. doi: 10.1128/JVI.01700-18

An ultraweak interaction in the intrinsically disordered replication machinery is essential for measles virus function. Milles S, Jensen MR, Lazert C, Guseva S, Ivashchenko S, Communie G, Maurin D, Gerlier D, Ruigrok RWH, Blackledge M.  Sci Adv. 2018, Aug 22;4(8),:eaat7778. doi: 10.1126/sciadv.aat7778. eCollection 2018 Aug

Organotypic brain cultures: a framework for studying CNS infection by neurotropic viruses and screening antiviral drugs. Welsch C.J., Lionnet C., TerzianC., Horvat B., Gerlier D., and Mathieu C. Bio-protocol 7(22): e2605, 2017, doi: 10.21769/BioProtoc.2605.

Broad spectrum antiviral activity for paramyxoviruses is modulated by biophysical properties of fusion inhibitory peptides. Mathieu C., Augusto M.T., Niewiesk S., Horvat B., Palermo L.M., Sanna G., Huey D., Castanho M.A.R.B., Porotto M., Santos N.C., Moscona A. Scient. Rep., 7:43610, 2017. doi:10.1038/srep43610

Measles virus infection of human keratinocytes: Possible link between measles and atopic. Gourru-Lesimple G., Mathieu C., Thevenet T., Guillaume-Vasselin V., Jégou J.F., Boer C.G., TomczakK., Bloyet L.M., Giraud C., Grande S., Goujon C., Cornu C. and Horvat B. Dermatol. Science, Feb 10, 2017, doi: 10.1016/j.jdermsci.2017.01.015

INSERM actualité

In vivo efficacy of measles virus fusion protein-derived peptides is modulated by properties of self-assembly and membrane residence. Figueira T.N., Palermo L.M., Veiga A.S., Huey D., Alabi C.A., Santos N.C., Welsch J.C., Mathieu C., Horvat B., Niewiesk S., Moscona A., Castanho M.A.R.B. and Porotto M. J. Virol. 91(1): e0554-16 2017. PMID: 27733647

Understanding the interaction between henipaviruses and their natural host, fruit bats: paving the way towards control of highly lethal infection in humans. Enchery F., Horvat 2017 Internat. Rev. Immunol. Jan 6:1-14. doi: 10.1080/08830185.2016.1255883.

Modulation of Re-initiation of Measles Virus Transcription at Intergenic Regions by PXD to NTAIL Binding Strength.
Bloyet LM, Brunel J, Dosnon M, Hamon V, Erales J, Gruet A, Lazert C, Bignon C, Roche P, Longhi S, Gerlier D.
PLoS Pathog. 2016 Dec 9;12(12):e1006058. doi: 10.1371/journal.ppat.1006058.

Protection from Hendra virus infection with Canarypox recombinant vaccine.
Guillaume-Vasselin V., Lemaitre L., Dhondt K.P., Tedeschi L, Poulard A., Charreyre C. and Horvat B.
Nature pj Vaccines, 1: 16003, 2016, doi:10.1038/npjvaccines.2016.3

Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5.
Uchikawa E, Lethier M, Malet H, Brunel J, Gerlier D, Cusack S.
Mol Cell 62, 586-602, 2016, doi: 10.1016/j.molcel.2016.04.021.

Requirement of HSP90 chaperoning in addition to phosphoprotein for folding but not for supporting enzymatic activities of measles and Nipah virus L polymerases.
Bloyet LM, Welsch J, Enchery F, Mathieu C, de Breyne S, Horvat B, Grigorov B, Gerlier D.
J Virol. 90(15):6642-56, 2016. doi: 10.1128/JVI.00602-16

Intradermal immunisation using the TLR3-ligand Poly (I:C) as adjuvant induces mucosal antibody responses and protects against genital HSV-2 infection. Bardel E., Doucet-Ladeveze R., Mathieu C., Harandi A.M., Dubois D. and Kaiserlian D. Nature pj Vaccines, 1: 16010, 2016. doi:10.1038/npjvaccines.2016.10

Latency Entry of Herpes Simplex Virus 1 Is Determined by the Interaction of Its Genome with the Nuclear Environment. Maroui MA, Callé A, Cohen C, Streichenberger N, Texier P, Takissian J, Rousseau A, Poccardi N, Welsch J, Corpet A, Schaeffer L, Labetoulle M, Lomonte P. PLoS Pathog. 2016 Sep 12;12(9):e1005834

Fuzzy regions in an intrinsically disordered protein impair protein-protein interactions.
Gruet A, Dosnon M, Blocquel D, Brunel J, Gerlier D, Das RK, Bonetti D, Gianni S, Fuxreiter M, Longhi S, Bignon C.
FEBS J.  283(4):576-94, 2016. doi: 10.1111/febs.13631

Heparan Sulfate-dependent enhancement of Henipavirus infection.
Mathieu C., Dhondt K.P., Châlons M., Mély S., Raoul H., Negre D., Cosset F.L., Gerlier D., Vivès R.R., and Horvat B.
mBio, 6(2): e02427-14, 2015. doi: 10.1128/mBio.02427-14

Measles virus hemagglutinin triggers intracellular signaling in CD150-expressing dendritic cells and inhibits immune response.
Romanets-Korbut O., Kovalevska L., Seya T., Sidorenko S.P.,  Horvat B.
Cell & Mol Immunol. 13:828-838, 2016. doi: 10.1038/cmi.2015.55

Kinetic discrimination of self/non-self RNA by the ATPase activity of RIG-I and MDA5.
Louber J, Brunel J, Uchikawa E, Cusack S, Gerlier D.
BMC Biol. 28;13:54, 2015. doi: 10.1186/s12915-015-0166-9

Expression of CD150 in tumors of the central nervous system: identification of a novel isoform.
Romanets-Korbut O., Najakshin A.M., Yurchenko M., Malysheva T.A., Kovalevska L., Shlapatska L.M., Zozulya Y.A., Taranin A.V.,  Horvat B., Sidorenko S.P.
Plos One, 10(2):e0118302, 2015. doi: 10.1371/journal.pone.0118302

Prevention of Measles infection by intranasal delivery of fusion inhibitory peptides.
Mathieu C., Huey D., Jurgens E., Welsch J.C., DeVito I., Talekar A., Horvat B., Niewiesk S., Moscona A., and Porotto M.
J. Virol. 89(2):1143-1155, 2015. doi: 10.1128/JVI.02417-14

Suppression of Smad-1 mRNA expression level by Smad-2 likely control dichotomy of NF-κB and Smads mediated activation.
Slade N., Zorić A., Horvat B., Vukšić M., Kostović I., Poljak L.
Immunobiology. 220(1): 48-53, 2015. doi: 10.1016/j.imbio.2014.09.003

Measles fusion machinery is dysregulated in neuropathogenic variants,
JurgensE.M., Mathieu C., Palermo L.M., Hardie D., Horvat B., Moscona A.,and Porotto M.
mBio, 2015 Feb 10;6(1). pii: e02528-14. doi: 10.1128/mBio.02528-14

Henipavirus pathogenesis and anti-viral approaches.
Mathieu C. & Horvat B.
Expert Rev Anti Infect Ther 29:1-12, doi: 10.1586/14787210.2015.1001838., 2015

Measles Virus: Identification in the M Protein Primary Sequence of a Potential Molecular Marker for Subacute Sclerosing Panencephalitis.
Kweder, H., Ainouze, M., Brunel, J., Gerlier, D., Manet, E., and Buckland, R. (2015).
Adv Virol 2015, 2015:769837. doi: 10.1155/2015/769837

RIG-I self-oligomerization is either dispensable or very transient for signal transduction.
Louber, J., Kowalinski, E., Bloyet, L-M., Brunel, J., Cusack, S., Gerlier, D.
PLoS One, 2014, 26;9(9):e108770. doi: 10.1371/journal.pone.0108770.

Sequence of events in measles virus replication: role of phosphoprotein-nucleocapsid interactions.
Brunel, J. Chopy, D.,Dosnon, M. Bloyet, L-M. Devaux, P., Urzua, E., Cattaneo, R., Longhi, S. Gerlier, D.
J. Virol. 2014,  88(18):10851-63. doi: 10.1128/JVI.00664-14.

Human Herpesvirus 6A infection in CD46 transgenic mice: viral prevalence in the brain and increased production of proinflammatory cytokines via TLR9.
Reynaud J., Jégou J.F., Welsch J., Horvat. B.
J. Virol. 2014, 88 (10): 5421-5436, 2014. doi: 10.1128/JVI.03763-13.

Recent developments in animal models for human herpesvirus 6A and 6B.
Horvat B., Berges B.K., Lusso P.
Curr. Opin. Virol. 2014, 9 :97-103, 2014. doi: 10.1016/j.coviro.2014.09.012

Fatal measles virus infection prevented by brain-penetrant fusion inhibitors.
Welsch JC, Talekar A, Mathieu C, Pessi A, Moscona A, Horvat B, Porotto M.
J Virol. 2013 Dec;87(24):13785-94. doi: 10.1128/JVI.02436-13.

Animal models for human herpesvirus 6 infection.
Reynaud JM, Horvat B.
Front Microbiol. 2013 Jul 4;4:174. doi: 10.3389/fmicb.2013.00174.

Dissecting Partner Recognition by an Intrinsically Disordered Protein Using Descriptive Random Mutagenesis.
Gruet A, Dosnon M, Vassena A, Lombard V, Gerlier D, Bignon C, Longhi S.
J Mol Biol. 2013 Jun 25. doi:pii: S0022-2836(13)00405-1. 10.1016/j.jmb.2013.06.025.

The V protein of Tioman virus is incapable of blocking type I interferon signaling in human cells.
Caignard G, Lucas-Hourani M, Dhondt KP, Labernardière JL, Petit T, Jacob Y, Horvat B, Tangy F, Vidalain PO.
PLoS One. 2013;8(1):e53881. doi: 10.1371/journal.pone.0053881.

Protection against henipavirus infection by use of recombinant adeno-associated virus-vector vaccines.
Ploquin A, Szécsi J, Mathieu C, Guillaume V, Barateau V, Ong KC, Wong KT, Cosset FL, Horvat B, Salvetti A.
J Infect Dis. 2013 Feb 1;207(3):469-78. doi: 10.1093/infdis/jis699.

Type I interferon signaling protects mice from lethal henipavirus infection.
Dhondt KP, Mathieu C, Chalons M, Reynaud JM, Vallve A, Raoul H, Horvat B.
J Infect Dis. 2013 Jan 1;207(1):142-51. doi: 10.1093/infdis/jis653

Mechanism for active membrane fusion triggering by morbillivirus attachment protein.
Ader N, Brindley M, Avila M, Örvell C, Horvat B, Hiltensperger G, Schneider-Schaulies J, Vandevelde M, Zurbriggen A, Plemper RK, Plattet P.
J Virol. 2013 Jan;87(1):314-26. doi: 10.1128/JVI.01826-12.

Nonstructural Nipah virus C protein regulates both the early host proinflammatory response and viral virulence.
Mathieu C, Guillaume V, Volchkova VA, Pohl C, Jacquot F, Looi RY, Wong KT, Legras-Lachuer C, Volchkov VE, Lachuer J, Horvat B.
J Virol. 2012 Oct;86(19):10766-75. doi: 10.1128/JVI.01203-12.

A general strategy to endow natural fusion-protein-derived peptides with potent antiviral activity.
Pessi A, Langella A, Capitò E, Ghezzi S, Vicenzi E, Poli G, Ketas T, Mathieu C, Cortese R, Horvat B, Moscona A, Porotto M.
PLoS One. 2012;7(5):e36833. doi: 10.1371/journal.pone.0036833.

Emerging zoonotic viruses: new lessons on receptor and entry mechanisms.
Gerlier D.
Curr Opin Virol. 2011 Jul;1(1):27-34. doi: 10.1016/j.coviro.2011.05.014.

Rapid screening for entry inhibitors of highly pathogenic viruses under low-level biocontainment.
Talekar A, Pessi A, Glickman F, Sengupta U, Briese T, Whitt MA, Mathieu C, Horvat B, Moscona A, Porotto M.
PLoS One. 2012;7(3):e30538. doi: 10.1371/journal.pone.0030538.

Lethal Nipah virus infection induces rapid overexpression of CXCL10.
Mathieu C, Guillaume V, Sabine A, Ong KC, Wong KT, Legras-Lachuer C, Horvat B.
PLoS One. 2012;7(2):e32157. doi: 10.1371/journal.pone.0032157.

[RIG-I: a viral RNA detector molecular switch].
Kowalinski E, Louber J, Gerlier D, Cusack S.
Med Sci (Paris). 2012 Feb;28(2):136-8. doi: 10.1051/medsci/2012282006.

Plasticity in structural and functional interactions between the phosphoprotein and nucleoprotein of measles virus.
Shu Y, Habchi J, Costanzo S, Padilla A, Brunel J, Gerlier D, Oglesbee M, Longhi S.
J Biol Chem. 2012 Apr 6;287(15):11951-67. doi: 10.1074/jbc.M111.333088.

Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA.
Kowalinski E, Lunardi T, McCarthy AA, Louber J, Brunel J, Grigorov B, Gerlier D, Cusack S.
Cell. 2011 Oct 14;147(2):423-35. doi: 10.1016/j.cell.2011.09.039.

Virus-driven conditional expression of an interferon antagonist as a tool to circumvent host restriction.
Gerlier D.
Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17239-40. doi: 10.1073/pnas.1114431108.

Rapid titration of measles and other viruses: optimization with determination of replication cycle length.
Grigorov B, Rabilloud J, Lawrence P, Gerlier D.
PLoS One. 2011;6(9):e24135. doi: 10.1371/journal.pone.0024135.

Interplay between innate immunity and negative-strand RNA viruses: towards a rational model.
Gerlier D, Lyles DS.
Microbiol Mol Biol Rev. 2011 Sep;75(3):468-90, second page of table of contents. doi: 10.1128/MMBR.00007-11.

Molecular characterization of measles virus strains causing subacute sclerosing panencephalitis in France in 1977 and 2007.
Moulin E, Beal V, Jeantet D, Horvat B, Wild TF, Waku-Kouomou D.
J Med Virol. 2011 Sep;83(9):1614-23. doi: 10.1002/jmv.22152.

Nipah virus uses leukocytes for efficient dissemination within a host.
Mathieu C, Pohl C, Szecsi J, Trajkovic-Bodennec S, Devergnas S, Raoul H, Cosset FL, Gerlier D, Wild TF, Horvat B.
J Virol. 2011 Aug;85(15):7863-71. doi: 10.1128/JVI.00549-11.

Cellular receptors, differentiation and endocytosis requirements are key factors for type I IFN response by human epithelial, conventional and plasmacytoid dendritic infected cells by measles virus.
Duhen T, Herschke F, Azocar O, Druelle J, Plumet S, Delprat C, Schicklin S, Wild TF, Rabourdin-Combe C, Gerlier D, Valentin H.
Virus Res. 2010 Sep;152(1-2):115-25. doi: 10.1016/j.virusres.2010.06.013.

Co-circulation of multiple measles virus genotypes during an epidemic in France in 2008.
Waku-Kouomou D, Freymuth F, du Châtelet IP, Wild TF, Horvat B.
J Med Virol. 2010 May;82(6):1033-43. doi: 10.1002/jmv.21766.

Experimental infection of squirrel monkeys with nipah virus.
Marianneau P, Guillaume V, Wong T, Badmanathan M, Looi RY, Murri S, Loth P, Tordo N, Wild F, Horvat B, Contamin H.
Emerg Infect Dis. 2010 Mar;16(3):507-10. doi: 10.3201/eid1603.091346.

PolyI:C plus IL-2 or IL-12 induce IFN-gamma production by human NK cells via autocrine IFN-beta.
Duluc D, Tan F, Scotet M, Blanchard S, Frémaux I, Garo E, Horvat B, Eid P, Delneste Y, Jeannin P.
Eur J Immunol. 2009 Oct;39(10):2877-84. doi: 10.1002/eji.200838610.

iNKT cell development is orchestrated by different branches of TGF-beta signaling.
Doisne JM, Bartholin L, Yan KP, Garcia CN, Duarte N, Le Luduec JB, Vincent D, Cyprian F, Horvat B, Martel S, Rimokh R, Losson R, Benlagha K, Marie JC.
J Exp Med. 2009 Jun 8;206(6):1365-78. doi: 10.1084/jem.20090127.

The interaction between the measles virus nucleoprotein and the Interferon Regulator Factor 3 relies on a specific cellular environment.
Colombo M, Bourhis JM, Chamontin C, Soriano C, Villet S, Costanzo S, Couturier M, Belle V, Fournel A, Darbon H, Gerlier D, Longhi S.
Virol J. 2009 May 15;6:59. doi: 10.1186/1743-422X-6-59.

Acute Hendra virus infection: Analysis of the pathogenesis and passive antibody protection in the hamster model.
Guillaume V, Wong KT, Looi RY, Georges-Courbot MC, Barrot L, Buckland R, Wild TF, Horvat B.
Virology. 2009 May 10;387(2):459-65. doi: 10.1016/j.virol.2009.03.001.

Interplay between virus-specific effector response and Foxp3 regulatory T cells in measles virus immunopathogenesis.
Sellin CI, Jégou JF, Renneson J, Druelle J, Wild TF, Marie JC, Horvat B.
PLoS One. 2009;4(3):e4948. doi: 10.1371/journal.pone.0004948.

Measles virus interaction with host cells and impact on innate immunity.
Gerlier D, Valentin H.
Curr Top Microbiol Immunol. 2009;329:163-91.

Generation of mice with conditionally activated transforming growth factor beta signaling through the TbetaRI/ALK5 receptor.
Bartholin L, Cyprian FS, Vincent D, Garcia CN, Martel S, Horvat B, Berthet C, Goddard-Léon S, Treilleux I, Rimokh R, Marie JC.
Genesis. 2008 Dec;46(12):724-31. doi: 10.1002/dvg.20425.

Human C3 deficiency associated with impairments in dendritic cell differentiation, memory B cells, and regulatory T cells.
Ghannam A, Pernollet M, Fauquert JL, Monnier N, Ponard D, Villiers MB, Péguet-Navarro J, Tridon A, Lunardi J, Gerlier D, Drouet C.
J Immunol. 2008 Oct 1;181(7):5158-66.

Refined study of the interaction between HIV-1 p6 late domain and ALIX.
Lazert C, Chazal N, Briant L, Gerlier D, Cortay JC.
Retrovirology. 2008 May 13;5:39. doi: 10.1186/1742-4690-5-39.

High-density rafts preferentially host the complement activator measles virus F glycoprotein but not the regulators of complement activation.
Ghannam A, Hammache D, Matias C, Louwagie M, Garin J, Gerlier D.
Mol Immunol. 2008 Jun;45(11):3036-44. doi: 10.1016/j.molimm.2008.03.013.

Wild type measles virus attenuation independent of type I IFN.
Druelle J, Sellin CI, Waku-Kouomou D, Horvat B, Wild FT.
Virol J. 2008 Feb 3;5:22. doi: 10.1186/1743-422X-5-22

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