Oncogenèse rétrovirale

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Publications

2019

HTLV-1 infection of myeloid cells: from transmission to immune alterations.
Rocamonde B, Carcone A, Mahieux R, Dutartre H.
Retrovirology. 2019 Dec 23;16(1):45. doi: 10.1186/s12977-019-0506-x. Review.

STLV-1 as a model for studying HTLV-1 infection.
Jégado B, Kashanchi F, Dutartre H, Mahieux R.
Retrovirology. 2019 Dec 16;16(1):41. doi: 10.1186/s12977-019-0503-0. Review.

SQSTM-1/p62 potentiates HTLV-1 Tax-mediated NF-κB activation through its ubiquitin binding function.
Schwob A, Teruel E, Dubuisson L, Lormières F, Verlhac P, Abudu YP, Gauthier J, Naoumenko M, Cloarec-Ung FM, Faure M, Johansen T, Dutartre H, Mahieux R, Journo C.
Sci Rep. 2019 Nov 5;9(1):16014. doi: 10.1038/s41598-019-52408-x.

The interferon stimulated gene 20 protein (ISG20) is an innate defense antiviral factor that discriminates self versus non-self translation.
Wu N, Nguyen XN, Wang L, Appourchaux R, Zhang C, Panthu B, Gruffat H, Journo C, Alais S, Qin J, Zhang N, Tartour K, Catez F, Mahieux R, Ohlmann T, Liu M, Du B, Cimarelli A.
PLoS Pathog. 2019 Oct 10;15(10):e1008093. doi: 10.1371/journal.ppat.1008093. eCollection 2019 Oct.

Complete Genome Sequence of a Papio anubis Simian Foamy Provirus.
Jegado B, Mahieux R.
Microbiol Resour Announc. 2019 Oct 3;8(40). pii: e01063-19. doi: 10.1128/MRA.01063-19.

Lyon, a critical place for performing Virology research.
Gerlier D, Gruffat H, Mahieux R.
Virologie (Montrouge). 2019 Mar 1;23(2):43-44. doi: 10.1684/vir.2019.0766. French. No abstract available.

Sensing of cell-associated HTLV by plasmacytoid dendritic cells is regulated by dense β-galactoside glycosylation.
Sonia Assil1*, Nicolas Futsch*, Elodie Décembre, Sandrine Alais, Antoine Gessain, François-Loïc Cosset, Renaud Mahieux, Marlène Dreux** and Hélène Dutartre**.
PLoS Pathog. 2019 Feb 28;15(2):e1007589. doi: 10.1371/journal.ppat.1007589. eCollection 2019 Feb.. *: co-first; **: co-corresponding

 

2018

STLV-1 co-infection is correlated with an increased SFV proviral load in the peripheral blood of SFV/STLV-1 naturally infected non-human primates.
Alais S, Pasquier A, Jegado B, Journo C, Rua R, Gessain A, Tobaly-Tapiero J, Lacoste R, Turpin J, Mahieux R.
PLoS Negl Trop Dis. 2018 Oct 1;12(10):e0006812. doi:10.1371/journal.pntd.0006812.

Cytokine Networks Dysregulation during HTLV-1 Infection and Associated Diseases.
Futsch N, Prates G, Mahieux R, Casseb G, Dutartre H.
Viruses. 2018. 10: 691

How to Control HTLV-1-Associated Diseases: Preventing de Novo Cellular Infection Using Antiviral Therapy.
Pasquier A, Alais S, Roux L, Thoulouze MI, Alvarez K, Journo C, Dutartre H, Mahieux R.
Frontiers in Microbiology 2018, vol 9; doi: 10.3389/fmicb.2018.00278

Stability of HTLV-2 Antisense Protein is Controlled by PML Nuclear Bodies in a SUMO-Dependent Manner.
Dubuisson L, Lormières F, Fochi S, Turpin J, Pasquier A, Douceron E, Oliva A, Bazarbachi A, Lallemand-Breitenbach V, de Thé H, Journo C, Mahieux R.
Oncogene. 2018 Mar 6. doi: 10.1038/s41388-018-0163-x.

un double effet antiviral des IFITM sur les virus enveloppés.
Jegado B, Journo C, Mahieux R.
Med. Sci. 2018, 34, 214-217

 

2017

Whole body clonality analysis in an aggressive STLV-1 associated leukemia (ATLL) reveals an unexpected clonal complexity.
Turpin J, Alais S, Marçais A, Bruneau J, Melamed A, Gadot N, Tanaka Y, Hermine O, Melot S, Lacoste R, Bangham CR, Mahieux R.
Cancer Lett. 2017 Mar 28;389:78-85. doi: 10.1016/j.canlet.2016.12.022.

Quantitative Analysis of Human T-Lymphotropic Virus Type 1 (HTLV-1) Infection Using Co-Culture with Jurkat LTR-Luciferase or Jurkat LTR-GFP Reporter Cells.
Alais S, Dutartre H, Mahieux R.
Methods Mol Biol. 2017;1582:47-55. doi: 10.1007/978-1-4939-6872-5_4.

Dendritic cell maturation, but not type I interferon exposure, restricts infection by HTLV-1, and viral transmission to T-cells.
Rizkallah G, Alais S, Futsch N, Tanaka Y, Journo C, Mahieux R, Dutartre H.
PLoS Pathog. 2017 Apr 20;13(4):e1006353. doi: 10.1371/journal.ppat.1006353.

Virologie, enseignement et recherche, un sujet d’avenir.
Mahieux R.
Virologie. 2017.21: 197-198

How does susceptibility to HTLV-1 infection varies with the maturation state of dendritic cells.
Rizkallah G, Journo C, Mahieux R, Dutartre H.
Future Virology. 12.

HTLV-1, the Other Pathogenic Yet Neglected Human Retrovirus: From Transmission to Therapeutic Treatment.
Futsch N, Mahieux R, Dutartre H.
Viruses. 2017 Dec 21;10(1). pii: E1. doi: 10.3390/v10010001.

Quand le cytosquelette d’actine fait le jeu des rétrovirus.
Teruel É, Rizkallah G, Journo C, Dutartre H
Med Sci. 2017. 33:839-842.

Reducing the global burden of HTLV-1 infection: An agenda for research and action.
Willems L, Hasegawa H, Accolla R, Bangham C, Bazarbachi A, Bertazzoni U, Carneiro-Proietti AB, Cheng H, Chieco-Bianchi L, Ciminale V, Coelho-Dos-Reis J, Esparza J, Gallo RC, Gessain A, Gotuzzo E, Hall W, Harford J, Hermine O, Jacobson S, Macchi B, Macpherson C, Mahieux R, Matsuoka M, Murphy E, Peloponese JM, Simon V, Tagaya Y, Taylor GP, Watanabe T, Yamano Y.
Antiviral Res. 2017 Jan;137:41-48. doi: 10.1016/j.antiviral.2016.10.015.

 

2016

Cell-Free versus Cell-to-Cell Infection by Human Immunodeficiency Virus Type 1 and Human T-Lymphotropic Virus Type 1: Exploring the Link among Viral Source, Viral Trafficking, and Viral Replication.
Dutartre H, Clavière M, Journo C, Mahieux R.
J Virol. 2016 Aug 12;90(17):7607-17. doi: 10.1128/JVI.00407-16.

Screening transplant donors for HTLV-1 and -2.
Gallo RC, Willems L, Hasegawa H and the members of the Global Network’s task force on HTLV-1.
Blood. 2016. 128; 3029-3031.

Rétrovirus humains T-lymphotropes de type 1 et 2.
Journo C, Mahieux R.
Encyclopédie Médicale et Chirurgicale. Elsevier. 2016. 13: 1-12.

Unanchored ubiquitin chains: a new viral target for NF-κB activation.
Schwob A, Mahieux R, Journo C.
Med Sci (Paris). 2016 Apr;32(4):329-32. doi: 10.1051/medsci/20163204006

Les virus géants ont-ils aussi un système immunitaire adaptatif ?
Journo C, Mahieux R.
Virologie. 2016. 20: 141-142.

La bactérie wolbachia a un effet inhibiteur sur Chikungunya dans le cadre d’un co-infection in cellula chez le moustique Aedes albopictus.
Bendorius M, Viet Chau Linh N, Mahieux R, Schwob A.
Virologie 20:248-249.

Intercellular transmission of HTLV-1: not all mechanisms have been revealed.
Rizkallah G, Mahieux R, Dutartre H.
Med Sci (Paris). 2015 Jun-Jul;31(6-7):629-37. doi: 10.1051/medsci/20153106016

Human Lymphotropic viruses: HTLV-1 and HTLV-2. The agents. Part B. RNA viruses.
Bruhn R, Mahieux R, Murphy E.
Clinical Virology. ASM Press. p 1-24. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi:10.1128/9781555819439.chapter 33: 771-794.

Discovery and characterization of auxiliary proteins encoded by type 3 simian T-cell lymphotropic viruses.
Turpin J, Journo C, Ko NL, Sinet F, Carpentier A, Galioot A, Edwards D, Vandamme AM, Gazzolo L, Duc Dodon M, Gessain A, Kashanchi F, Balansard I, Lacoste R, Mahieux R.
J Virol. 2015 Jan 15;89(2):931-51. doi: 10.1128/JVI.02150-14.

Origin of HTLV-1 in hunters of nonhuman primates in Central Africa.
Kazanji M, Mouinga-Ondémé A, Lekana-Douki-Etenna S, Caron M, Makuwa M, Mahieux R*, Gessain A*. * co-auteurs
J Infect Dis. 2015 Feb 1;211(3):361-5. doi: 10.1093/infdis/jiu464

A Transgenic Drosophila melanogaster Model To Study Human T-Lymphotropic Virus Oncoprotein Tax-1-Driven Transformation In Vivo.
Shirinian M, Kambris Z, Hamadeh L, Grabbe C, Journo C, Mahieux R, Bazarbachi A.
J Virol. 2015 Aug;89(15):8092-5. doi: 10.1128/JVI.00918-15.

A vaccine against HTLV-1 HBZ makes sense.
Mahieux R.
Blood. 2015 Aug 27;126(9):1052-3. doi: 10.1182/blood-2015-06-652040.

Viral Source-Independent High Susceptibility of Dendritic Cells to Human T-Cell Leukemia Virus Type 1 Infection Compared to That of T Lymphocytes.
Alais S, Mahieux R, Dutartre H.
J Virol. 2015 Oct;89(20):10580-90. doi: 10.1128/JVI.01799-15

 

2014

ADAR1 enhances HTLV-1 and HTLV-2 replication through inhibition of PKR activity.
Cachat A, Alais S, Chevalier SA, Journo C, Fusil F, Dutartre H, Boniface A, Ko NL, Gessain A, Cosset FL, Suspène R, Vartanian JP, Mahieux R.
Retrovirology. 2014 Nov 12;11:93. doi: 10.1186/s12977-014-0093-9.

Gem-induced cytoskeleton remodeling increases cellular migration of HTLV-1-infected cells, formation of infected-to-target T-cell conjugates and viral transmission.
Chevalier SA, Turpin J, Cachat A, Afonso PV, Gessain A, Brady JN, Pise-Masison CA, Mahieux R.
PLoS Pathog. 2014 Feb 27;10(2):e1003917. doi: 10.1371/journal.ppat.1003917.

 

2013

Human T cell leukemia virus type 2 tax-mediated NF-κB activation involves a mechanism independent of Tax conjugation to ubiquitin and SUMO.
Journo C, Bonnet A, Favre-Bonvin A, Turpin J, Vinera J, Côté E, Chevalier SA, Kfoury Y, Bazarbachi A, Pique C, Mahieux R.
J Virol. 2013 Jan;87(2):1123-36. doi: 10.1128/JVI.01792-12.

Alpha interferon restricts human T-lymphotropic virus type 1 and 2 de novo infection through PKR activation.
Cachat A, Chevalier SA, Alais S, Ko NL, Ratner L, Journo C, Dutartre H, Mahieux R.
J Virol. 2013 Dec;87(24):13386-96. doi: 10.1128/JVI.02758-13.

HTLV-3/4 and simian foamy retroviruses in humans: discovery, epidemiology, cross-species transmission and molecular virology.
Gessain A, Rua R, Betsem E, Turpin J, Mahieux R.
Virology. 2013 Jan 5;435(1):187-99. doi: 10.1016/j.virol.2012.09.035. Review.

Les virus oncogènes.
Journo C, Cosset FL, Mahieux R.
Ed Belin. 2013.125-135.

Forefront studies on HTLV-1 oncogenesis.
Mahieux R, Watanabe T.
Front Microbiol. 2013 Jun 18;4:156. doi: 10.3389/fmicb.2013.00156.