Virus enveloppés, vecteurs et immunothérapie

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Publications originales (depuis 2008)

Direct antiviral properties of TLR ligands against HBV replication in immune-competent hepatocytes. Lucifora J, Bonnin M, Aillot L, Fusil F, Maadadi S, Dimier L, Michelet M, Floriot O, Ollivier A, Rivoire M, Ait-Goughoulte M, Daffis S, Fletcher SP, Salvetti A, Cosset FL, Zoulim F, Durantel D (2018) Sci Rep 8: 5390

A protein coevolution method uncovers critical features of the Hepatitis C Virus fusion mechanism. Douam F, Fusil F, Enguehard M, Dib L, Nadalin F, Schwaller L, Hrebikova G, Mancip J, Mailly L, Montserret R, Ding Q, Maisse C, Carlot E, Xu K, Verhoeyen E, Baumert TF, Ploss A, Carbone A, Cosset FL, Lavillette D (2018) PLoS pathogens 14: e1006908

A Point Mutation in the N-Terminal Amphipathic Helix alpha0 in NS3 Promotes Hepatitis C Virus Assembly by Altering Core Localization to the Endoplasmic Reticulum and Facilitating Virus Budding. Yan Y, He Y, Boson B, Wang X, Cosset FL, Zhong J (2017) Journal of virology 91

Detection of the hepatitis B virus (HBV) covalently-closed-circular DNA (cccDNA) in mice transduced with a recombinant AAV-HBV vector. Lucifora J, Salvetti A, Marniquet X, Mailly L, Testoni B, Fusil F, Inchauspe A, Michelet M, Michel ML, Levrero M, Cortez P, Baumert TF, Cosset FL, Challier C, Zoulim F, Durantel D (2017) Antiviral research 145: 14-19

Measles virus envelope pseudotyped lentiviral vectors transduce quiescent human HSCs at an efficiency without precedent. Levy C, Amirache F, Girard-Gagnepain A, Frecha C, Roman-Rodriguez FJ, Bernadin O, Costa C, Negre D, Gutierrez-Guerrero A, Vranckx LS, Clerc I, Taylor N, Thielecke L, Cornils K, Bueren JA, Rio P, Gijsbers R, Cosset FL, Verhoeyen E (2017) Blood Adv 1: 2088-2104

Polo-like-kinase 1 is a proviral host factor for hepatitis B virus replication. Diab A, Foca A, Fusil F, Lahlali T, Jalaguier P, Amirache F, N’Guyen L, Isorce N, Cosset FL, Zoulim F, Andrisani O, Durantel D (2017) Hepatology (Baltimore, Md 66: 1750-1765

The amino-terminus of the hepatitis C virus (HCV) p7 viroporin and its cleavage from glycoprotein E2-p7 precursor determine specific infectivity and secretion levels of HCV particle types. Denolly S, Mialon C, Bourlet T, Amirache F, Penin F, Lindenbach B, Boson B, Cosset FL (2017) PLoS pathogens 13: e1006774

Baboon envelope pseudotyped lentiviral vectors: a highly efficient new tool to genetically manipulate T-cell acute lymphoblastic leukaemia-initiating cells. Costa C, Hypolite G, Bernadin O, Levy C, Cosset FL, Asnafi V, Macintyre E, Verhoeyen E, Tesio M (2017) Leukemia 31: 977-980

Hepatitis C virus has a genetically determined lymphotropism through co-receptor B7.2. Chen CL, Huang JY, Wang CH, Tahara SM, Zhou L, Kondo Y, Schechter J, Su L, Lai MM, Wakita T, Cosset FL, Jung JU, Machida K (2017) Nature communications 8: 13882

Daclatasvir Prevents Hepatitis C Virus Infectivity by Blocking Transfer of the Viral Genome to Assembly Sites. Boson B, Denolly S, Turlure F, Chamot C, Dreux M, Cosset FL (2017) Gastroenterology 152: 895-907 e14

Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes. Verrier ER, Colpitts CC, Bach C, Heydmann L, Zona L, Xiao F, Thumann C, Crouchet E, Gaudin R, Sureau C, Cosset FL, McKeating JA, Pessaux P, Hoshida Y, Schuster C, Zeisel MB, Baumert TF (2016) Cell reports 17: 1357-1368

Triggering the TCR Developmental Checkpoint Activates a Therapeutically Targetable Tumor Suppressive Pathway in T-cell Leukemia. Trinquand A, Dos Santos NR, Tran Quang C, Rocchetti F, Zaniboni B, Belhocine M, Da Costa de Jesus C, Lhermitte L, Tesio M, Dussiot M, Cosset FL, Verhoeyen E, Pflumio F, Ifrah N, Dombret H, Spicuglia S, Chatenoud L, Gross DA, Hermine O, Macintyre E et al. (2016) Cancer discovery 6: 972-85

Gene-corrected human Munc13-4-deficient CD8+ T cells can efficiently restrict EBV-driven lymphoproliferation in immunodeficient mice. Soheili T, Riviere J, Ricciardelli I, Durand A, Verhoeyen E, Derrien AC, Lagresle-Peyrou C, de Saint Basile G, Cosset FL, Amrolia P, Andre-Schmutz I, Cavazzana M (2016) Blood 128: 2859-2862

T- and B-cell responses to multivalent prime-boost DNA and viral vectored vaccine combinations against hepatitis C virus in non-human primates. Rollier CS, Verschoor EJ, Verstrepen BE, Drexhage JA, Paranhos-Baccala G, Liljestrom P, Sutter G, Arribillaga L, Lasarte JJ, Bartosch B, Cosset FL, Inchauspe G, Heeney JL (2016) Gene therapy 23: 753-759

Atad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells. Morozumi Y, Boussouar F, Tan M, Chaikuad A, Jamshidikia M, Colak G, He H, Nie L, Petosa C, de Dieuleveult M, Curtet S, Vitte AL, Rabatel C, Debernardi A, Cosset FL, Verhoeyen E, Emadali A, Schweifer N, Gianni D, Gut M et al. (2016) Journal of molecular cell biology 8: 349-62

Baboon envelope pseudotyped lentiviral vectors efficiently transduce human B cells and allow active factor IX B cell secretion in vivo in NOD/SCIDgammac-/- mice. Levy C, Fusil F, Amirache F, Costa C, Girard-Gagnepain A, Negre D, Bernadin O, Garaulet G, Rodriguez A, Nair N, Vandendriessche T, Chuah M, Cosset* FL, Verhoeyen* E (2016) Journal of thrombosis and haemostasis : JTH 14: 2478-2492

X-linked primary immunodeficiency associated with hemizygous mutations in the moesin (MSN) gene. Lagresle-Peyrou C, Luce S, Ouchani F, Soheili TS, Sadek H, Chouteau M, Durand A, Pic I, Majewski J, Brouzes C, Lambert N, Bohineust A, Verhoeyen E, Cosset FL, Magerus-Chatinet A, Rieux-Laucat F, Gandemer V, Monnier D, Heijmans C, van Gijn M et al. (2016) The Journal of allergy and clinical immunology 138: 1681-1689 e8

Haploinsufficiency for NR3C1, the gene encoding the glucocorticoid receptor, in blastic plasmacytoid dendritic cell neoplasms. Emadali A, Hoghoughi N, Duley S, Hajmirza A, Verhoeyen E, Cosset FL, Bertrand P, Roumier C, Roggy A, Suchaud-Martin C, Chauvet M, Bertrand S, Hamaidia S, Rousseaux S, Josserand V, Charles J, Templier I, Maeda T, Bruder-Costa J, Chaperot L et al. (2016) Blood 127: 3040-53

Acute hepatitis C virus infection induces anti-host cell receptor antibodies with virus-neutralizing properties. Tawar RG, Colpitts CC, Timm J, Fehm T, Roggendorf M, Meisel H, Meyer N, Habersetzer F, Cosset FL, Berg T, Zeisel MB, Baumert TF (2015) Hepatology (Baltimore, Md 62: 726-36

Atad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells. Morozumi Y, Boussouar F, Tan M, Chaikuad A, Jamshidikia M, Colak G, He H, Nie L, Petosa C, de Dieuleveult M, Curtet S, Vitte AL, Rabatel C, Debernardi A, Cosset FL, Verhoeyen E, Emadali A, Schweifer N, Gianni D, Gut M et al. (2015) Journal of molecular cell biology

Low cross-neutralization of hepatitis C correlates with liver disease in immunocompromized patients. Maurin G, Halgand B, Bruscella P, Fresquet J, Duclos-Vallee JC, Roque-Afonso AM, Cosset FL, Samuel D, Lavillette D, Feray C (2015) Aids 29: 1025-33

Heparan sulfate-dependent enhancement of henipavirus infection. Mathieu C, Dhondt KP, Chalons M, Mely S, Raoul H, Negre D, Cosset FL, Gerlier D, Vives RR, Horvat B (2015) mBio 6: e02427

Determinants Involved in Hepatitis C Virus and GB Virus B Primate Host Restriction. Marnata C, Saulnier A, Mompelat D, Krey T, Cohen L, Boukadida C, Warter L, Fresquet J, Vasiliauskaite I, Escriou N, Cosset FL, Rey FA, Lanford RE, Karayiannis P, Rose NJ, Lavillette D, Martin A (2015) Journal of virology 89: 12131-44

A Lentiviral Vector Allowing Physiologically Regulated Membrane-anchored and Secreted Antibody Expression Depending on B-cell Maturation Status. Fusil F, Calattini S, Amirache F, Mancip J, Costa C, Robbins JB, Douam F, Lavillette D, Law M, Defrance T, Verhoeyen E, Cosset FL (2015) Mol Ther 23: 1734-47

Hepatitis C Virus Envelope Glycoprotein E1 Forms Trimers at the Surface of the Virion. Falson P, Bartosch B, Alsaleh K, Tews BA, Loquet A, Ciczora Y, Riva L, Montigny C, Montpellier C, Duverlie G, Pecheur EI, le Maire M, Cosset FL, Dubuisson J, Penin F (2015) Journal of virology 89: 10333-46

Specialization of Hepatitis C Virus Envelope Glycoproteins for B Lymphocytes in Chronically Infected Patients. Douam F, Bobay LM, Maurin G, Fresquet J, Calland N, Maisse C, Durand T, Cosset FL, Feray C, Lavillette D (2015) Journal of virology 90: 992-1008

Functional and Biochemical Characterization of Hepatitis C Virus (HCV) Particles Produced in a Humanized Liver Mouse Model. Calattini S, Fusil F, Mancip J, Dao Thi VL, Granier C, Gadot N, Scoazec JY, Zeisel MB, Baumert TF, Lavillette D, Dreux M, Cosset FL (2015) The Journal of biological chemistry 290: 23173-87

Infection of Human Liver Myofibroblasts by Hepatitis C Virus: A Direct Mechanism of Liver Fibrosis in Hepatitis C. Aoudjehane L, Bisch G, Scatton O, Granier C, Gaston J, Housset C, Roingeard P, Cosset FL, Perdigao F, Balladur P, Wakita T, Calmus Y, Conti F (2015) PloS one 10: e0134141

The mycotoxin aflatoxin B1 stimulates Epstein-Barr virus-induced B-cell transformation in in vitro and in vivo experimental models. Accardi R, Gruffat H, Sirand C, Fusil F, Gheit T, Hernandez-Vargas H, Le Calvez-Kelm F, Traverse-Glehen A, Cosset FL, Manet E, Wild CP, Tommasino M (2015) Carcinogenesis 36: 1440-51

A multi-colour/multi-affinity marker set to visualize phosphoinositide dynamics in Arabidopsis. Simon ML, Platre MP, Assil S, van Wijk R, Chen WY, Chory J, Dreux M, Munnik T, Jaillais Y (2014) The Plant journal : for cell and molecular biology 77: 322-37

High levels of SOX5 decrease proliferative capacity of human B cells, but permit plasmablast differentiation. Rakhmanov M, Sic H, Kienzler AK, Fischer B, Rizzi M, Seidl M, Melkaoui K, Unger S, Moehle L, Schmit NE, Deshmukh SD, Ayata CK, Schuh W, Zhang Z, Cosset FL, Verhoeyen E, Peter HH, Voll RE, Salzer U, Eibel H et al. (2014) PloS one 9: e100328

Mutations in the H, F, or M Proteins Can Facilitate Resistance of Measles Virus to Neutralizing Human Anti-MV Sera. Kweder H, Ainouze M, Cosby SL, Muller CP, Levy C, Verhoeyen E, Cosset FL, Manet E, Buckland R (2014) Advances in virology 2014: 205617

Baboon envelope pseudotyped LVs outperform VSV-G-LVs for gene transfer into early-cytokine-stimulated and resting HSCs. Girard-Gagnepain A, Amirache F, Costa C, Levy C, Frecha C, Fusil F, Negre D, Lavillette D, Cosset FL, Verhoeyen E (2014) Blood 124: 1221-31

Activated macrophages promote hepatitis C virus entry in a tumor necrosis factor-dependent manner. Fletcher NF, Sutaria R, Jo J, Barnes A, Blahova M, Meredith LW, Cosset FL, Curbishley SM, Adams DH, Bertoletti A, McKeating JA (2014) Hepatology (Baltimore, Md 59: 1320-30

Critical interaction between E1 and E2 glycoproteins determines binding and fusion properties of hepatitis C virus during cell entry. Douam F, Dao Thi VL, Maurin G, Fresquet J, Mompelat D, Zeisel MB, Baumert TF, Cosset* FL, Lavillette* D (2014) Hepatology (Baltimore, Md 59: 776-88

Sensing of immature particles produced by dengue virus infected cells induces an antiviral response by plasmacytoid dendritic cells. Decembre E, Assil S, Hillaire ML, Dejnirattisai W, Mongkolsapaya J, Screaton GR, Davidson AD, Dreux M (2014) PLoS pathogens 10: e1004434

ADAR1 enhances HTLV-1 and HTLV-2 replication through inhibition of PKR activity. Cachat A, Alais S, Chevalier S, Journo C, Fusil F, Dutartre H, Boniface A, Ko N, Gessain A, Cosset FL, Suspene R, Vartanian JP, Mahieux R (2014) Retrovirology 11: 93

Up-Regulation of the ATP-Binding Cassette Transporter A1 Inhibits Hepatitis C Virus Infection. Bocchetta S, Maillard P, Yamamoto M, Gondeau C, Douam F, Lebreton S, Lagaye S, Pol S, Helle F, Plengpanich W, Guerin M, Bourgine M, Michel ML, Lavillette D, Roingeard P, le Goff W, Budkowska A (2014) PloS one 9: e92140

Mystery solved: VSV-G-LVs do not allow efficient gene transfer into unstimulated T cells, B cells, and HSCs because they lack the LDL receptor. Amirache F, Levy C, Costa C, Mangeot PE, Torbett BE, Wang CX, Negre D, Cosset FL, Verhoeyen E (2014) Blood 123: 1422-4

HRas signal transduction promotes hepatitis C virus cell entry by triggering assembly of the host tetraspanin receptor complex. Zona L, Lupberger J, Sidahmed-Adrar N, Thumann C, Harris HJ, Barnes A, Florentin J, Tawar RG, Xiao F, Turek M, Durand SC, Duong FH, Heim MH, Cosset FL, Hirsch I, Samuel D, Brino L, Zeisel MB, Le Naour F, McKeating JA et al. (2013) Cell host & microbe 13: 302-13

The postbinding activity of scavenger receptor class B type I mediates initiation of hepatitis C virus infection and viral dissemination. Zahid MN, Turek M, Xiao F, Dao Thi VL, Guerin M, Fofana I, Bachellier P, Thompson J, Delang L, Neyts J, Bankwitz D, Pietschmann T, Dreux M, Cosset FL, Grunert F, Baumert TF, Zeisel MB (2013) Hepatology (Baltimore, Md 57: 492-504

The antimalarial ferroquine is an inhibitor of hepatitis C virus. Vausselin T, Calland N, Belouzard S, Descamps V, Douam F, Helle F, Francois C, Lavillette D, Duverlie G, Wahid A, Feneant L, Cocquerel L, Guerardel Y, Wychowski C, Biot C, Dubuisson J (2013) Hepatology (Baltimore, Md 58: 86-97

Generation of transgenic mice expressing EGFP protein fused to NP68 MHC class I epitope using lentivirus vectors. Tomkowiak M, Ghittoni R, Teixeira M, Blanquier B, Szecsi J, Negre D, Aubert D, Coupet CA, Brunner M, Verhoeyen E, Thoumas JL, Cosset FL, Leverrier Y, Marvel J (2013) Genesis 51: 193-200

A multi-colour/multi-affinity marker set to visualize phosphoinositide dynamics in Arabidopsis. Simon ML, Platre MP, Assil S, van Wijk R, Chen WY, Chory J, Dreux M, Munnik T, Jaillais Y (2013) The Plant journal : for cell and molecular biology
Protection against henipavirus infection by use of recombinant adeno-associated virus-vector vaccines. Ploquin A, Szecsi J, Mathieu C, Guillaume V, Barateau V, Ong KC, Wong KT, Cosset FL, Horvat B, Salvetti A (2013) The Journal of infectious diseases 207: 469-78

Virus-like particle vaccine induces cross-protection against human metapneumovirus infections in mice. Levy C, Aerts L, Hamelin ME, Granier C, Szecsi J, Lavillette D, Boivin G, Cosset FL (2013) Vaccine 31: 2778-85

Epitope dampening monotypic measles virus hemagglutinin glycoprotein results in resistance to cocktail of monoclonal antibodies. Lech PJ, Tobin GJ, Bushnell R, Gutschenritter E, Pham LD, Nace R, Verhoeyen E, Cosset FL, Muller CP, Russell SJ, Nara PL (2013) PloS one 8: e52306

CD19 and CD20 Targeted Vectors Induce Minimal Activation of Resting B Lymphocytes. Kneissl S, Zhou Q, Schwenkert M, Cosset FL, Verhoeyen E, Buchholz CJ (2013) PloS one 8: e79047

Plant science and agricultural productivity: why are we hitting the yield ceiling? de Bossoreille de Ribou S, Douam F, Hamant O, Frohlich MW, Negrutiu I (2013) Plant science : an international journal of experimental plant biology 210: 159-76

TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells. Biroccio A, Cherfils-Vicini J, Augereau A, Pinte S, Bauwens S, Ye J, Simonet T, Horard B, Jamet K, Cervera L, Mendez-Bermudez A, Poncet D, Grataroli R, de Rodenbeeke CT, Salvati E, Rizzo A, Zizza P, Ricoul M, Cognet C, Kuilman T et al. (2013) Nature cell biology 15: 818-28

Low titer lentiviral transgenesis in rodents with simian immundeficiency virus vector. Bender B, Hoffmann OI, Negre D, Kvell K, Bosze Z, Hiripi L (2013) BioTechniques 55: 137-40

Stem cell factor-displaying simian immunodeficiency viral vectors together with a low conditioning regimen allow for long-term engraftment of gene-marked autologous hematopoietic stem cells in macaques. Verhoeyen E, Relouzat F, Cambot M, Costa C, Negre D, Legrand F, Joubert C, Grand RL, Cosset FL, Leboulch P, Dubart-Kupperschmitt A, Prost S (2012) Human gene therapy 23: 754-68

Efficient transduction of healthy and malignant plasma cells by lentiviral vectors pseudotyped with measles virus glycoproteins. Schoenhals M, Frecha C, Bruyer A, Caraux A, Veyrune JL, Jourdan M, Moreaux J, Cosset FL, Verhoeyen E, Klein B (2012) Leukemia 26: 1663-70

Matrigel-embedded 3D culture of Huh-7 cells as a hepatocyte-like polarized system to study hepatitis C virus cycle. Molina-Jimenez F, Benedicto I, Dao Thi VL, Gondar V, Lavillette D, Marin JJ, Briz O, Moreno-Otero R, Aldabe R, Baumert TF, Cosset FL, Lopez-Cabrera M, Majano PL (2012) Virology 425: 31-9

Glut1-mediated glucose transport regulates HIV infection. Loisel-Meyer S, Swainson L, Craveiro M, Oburoglu L, Mongellaz C, Costa C, Martinez M, Cosset FL, Battini JL, Herzenberg LA, Herzenberg LA, Atkuri KR, Sitbon M, Kinet S, Verhoeyen E, Taylor N (2012) Proceedings of the National Academy of Sciences of the United States of America 109: 2549-54

Lentiviral vectors displaying modified measles virus gp overcome pre-existing immunity in in vivo-like transduction of human T and B cells. Levy C, Amirache F, Costa C, Frecha C, Muller CP, Kweder H, Buckland R, Cosset* FL, Verhoeyen* E (2012) Mol Ther 20: 1699-712

Lumenal lipid metabolism: implications for lipoprotein assembly. Lehner R, Lian J, Quiroga AD (2012) Arterioscler Thromb Vasc Biol 32: 1087-93

Measles virus glycoprotein-pseudotyped lentiviral vectors are highly superior to vesicular stomatitis virus G pseudotypes for genetic modification of monocyte-derived dendritic cells. Humbert JM, Frecha C, Amirache Bouafia F, N’Guyen TH, Boni S, Cosset FL, Verhoeyen E, Halary F (2012) Journal of virology 86: 5192-203

Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus. Giang E, Dorner M, Prentoe JC, Dreux M, Evans MJ, Bukh J, Rice CM, Ploss A, Burton DR, Law M (2012) Proceedings of the National Academy of Sciences of the United States of America 109: 6205-10

A novel lentiviral vector targets gene transfer into human hematopoietic stem cells in marrow from patients with bone marrow failure syndrome and in vivo in humanized mice. Frecha C, Costa C, Negre D, Amirache F, Trono D, Rio P, Bueren J, Cosset* FL, Verhoeyen* E (2012) Blood 119: 1139-50

Mutations that alter use of hepatitis C virus cell entry factors mediate escape from neutralizing antibodies. Fofana I, Fafi-Kremer S, Carolla P, Fauvelle C, Zahid MN, Turek M, Heydmann L, Cury K, Hayer J, Combet C, Cosset FL, Pietschmann T, Hiet MS, Bartenschlager R, Habersetzer F, Doffoel M, Keck ZY, Foung SK, Zeisel MB, Stoll-Keller F et al. (2012) Gastroenterology 143: 223-233 e9

Short-range exosomal transfer of viral RNA from infected cells to plasmacytoid dendritic cells triggers innate immunity. Dreux M, Garaigorta U, Boyd B, Decembre E, Chung J, Whitten-Bauer C, Wieland S, Chisari FV (2012) Cell host & microbe 12: 558-70

Characterization of hepatitis C virus particle subpopulations reveals multiple usage of the scavenger receptor BI for entry steps. Dao Thi VL, Granier C, Zeisel MB, Guerin M, Mancip J, Granio O, Penin F, Lavillette D, Bartenschlager R, Baumert TF, Cosset* FL, Dreux* M (2012) The Journal of biological chemistry 287: 31242-57

TLX homeodomain oncogenes mediate T cell maturation arrest in T-ALL via interaction with ETS1 and suppression of TCRalpha gene expression. Dadi S, Le Noir S, Payet-Bornet D, Lhermitte L, Zacarias-Cabeza J, Bergeron J, Villarese P, Vachez E, Dik WA, Millien C, Radford I, Verhoeyen E, Cosset FL, Petit A, Ifrah N, Dombret H, Hermine O, Spicuglia S, Langerak AW, Macintyre EA et al. (2012) Cancer cell 21: 563-76

Distinct roles in folding, CD81 receptor binding and viral entry for conserved histidine residues of hepatitis C virus glycoprotein E1 and E2. Boo I, teWierik K, Douam F, Lavillette D, Poumbourios P, Drummer HE (2012) The Biochemical journal 443: 85-94

Clearance of genotype 1b hepatitis C virus in chimpanzees in the presence of vaccine-induced e1-neutralizing antibodies. Verstrepen BE, Depla E, Rollier CS, Mares G, Drexhage JA, Priem S, Verschoor EJ, Koopman G, Granier C, Dreux M, Cosset FL, Maertens G, Heeney JL (2011) The Journal of infectious diseases 204: 837-44

Mechanism of inhibition of enveloped virus membrane fusion by the antiviral drug arbidol. Teissier E, Zandomeneghi G, Loquet A, Lavillette D, Lavergne JP, Montserret R, Cosset FL, Bockmann A, Meier BH, Penin F, Pecheur EI (2011) PloS one 6: e15874
Hepatitis C Virus Is Primed by CD81 Protein for Low pH-dependent Fusion. Sharma NR, Mateu G, Dreux M, Grakoui A, Cosset FL, Melikyan GB (2011) The Journal of biological chemistry 286: 30361-76

Identification of Interactions in the E1E2 Heterodimer of Hepatitis C Virus Important for Cell Entry. Maurin G, Fresquet J, Granio O, Wychowski C, Cosset* FL, Lavillette* D (2011) The Journal of biological chemistry 286: 23865-76
Nipah Virus Uses Leukocytes for Efficient Dissemination within a Host. Mathieu C, Pohl C, Szecsi J, Trajkovic-Bodennec S, Devergnas S, Raoul H, Cosset FL, Gerlier D, Wild TF, Horvat B (2011) Journal of virology 85: 7863-71

EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy. Lupberger J, Zeisel MB, Xiao F, Thumann C, Fofana I, Zona L, Davis C, Mee CJ, Turek M, Gorke S, Royer C, Fischer B, Zahid MN, Lavillette D, Fresquet J, Cosset FL, Rothenberg SM, Pietschmann T, Patel AH, Pessaux P et al. (2011) Nature medicine 17: 589-95

A prime-boost strategy using virus-like particles pseudotyped for HCV proteins triggers broadly neutralizing antibodies in macaques. Garrone P, Fluckiger AC, Mangeot PE, Gauthier E, Dupeyrot-Lacas P, Mancip J, Cangialosi A, Du Chene I, Legrand R, Mangeot I, Lavillette D, Bellier B, Cosset* FL, Tangy* F, Klatzmann* D, Dalba* C (2011) Science translational medicine 3: 94ra71

Measles Virus Glycoprotein-Pseudotyped Lentiviral Vector-Mediated Gene Transfer into Quiescent Lymphocytes Requires Binding to both SLAM and CD46 Entry Receptors. Frecha C, Levy C, Costa C, Negre D, Amirache F, Buckland R, Russell SJ, Cosset* FL, Verhoeyen* E (2011) Journal of virology 85: 5975-85

The Mouse IAPE Endogenous Retrovirus Can Infect Cells through Any of the Five GPI-Anchored EphrinA Proteins. Dewannieux M, Vernochet C, Ribet D, Bartosch B, Cosset FL, Heidmann T (2011) PLoS pathogens 7: e1002309

A concerted action of hepatitis C virus p7 and nonstructural protein 2 regulates core localization at the endoplasmic reticulum and virus assembly. Boson B, Granio O, Bartenschlager R, Cosset FL (2011) PLoS pathogens 7: e1002144

TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage. Ye J, Lenain C, Bauwens S, Rizzo A, Saint-Leger A, Poulet A, Benarroch D, Magdinier F, Morere J, Amiard S, Verhoeyen E, Britton S, Calsou P, Salles B, Bizard A, Nadal M, Salvati E, Sabatier L, Wu Y, Biroccio A et al. (2010) Cell 142: 230-42

Production of infectious hepatitis C virus in primary cultures of human adult hepatocytes. Podevin P, Carpentier A, Pene V, Aoudjehane L, Carriere M, Zaidi S, Hernandez C, Calle V, Meritet JF, Scatton O, Dreux M, Cosset FL, Wakita T, Bartenschlager R, Demignot S, Conti F, Rosenberg AR, Calmus Y (2010) Gastroenterology 139: 1355-64

Fusogenic membrane glycoproteins induce syncytia formation and death in vitro and in vivo: a potential therapy agent for lung cancer. Lin EH, Salon C, Brambilla E, Lavillette D, Szecsi J, Cosset FL, Coll JL (2010) Cancer gene therapy 17: 256-65

Lentiviral vectors and transduction of human cancer B cells. Levy C, Frecha C, Costa C, Rachinel N, Salles G, Cosset* FL, Verhoeyen* E (2010) Blood 116: 498-500; author reply 500

Inhibition of hepatitis C virus infection by anti-claudin-1 antibodies is mediated by neutralization of E2-CD81-claudin-1 associations. Krieger SE, Zeisel MB, Davis C, Thumann C, Harris HJ, Schnober EK, Mee C, Soulier E, Royer C, Lambotin M, Grunert F, Dao Thi VL, Dreux M, Cosset FL, McKeating JA, Schuster C, Baumert TF (2010) Hepatology (Baltimore, Md 51: 1144-57

Transgenic rabbit production with simian immunodeficiency virus-derived lentiviral vector. Hiripi L, Negre D, Cosset FL, Kvell K, Czompoly T, Baranyi M, Gocza E, Hoffmann O, Bender B, Bosze Z (2010) Transgenic research 19: 799-808

Optimized gene transfer into human primary leukemic T cell with NOD-SCID/leukemia-initiating cell activity. Gerby B, Armstrong F, de la Grange PB, Medyouf H, Calvo J, Verhoeyen E, Cosset FL, Bernstein I, Amselem S, Boissel N, Dombret H, Leblanc T, Baruchel A, Landman-Parker J, Ballerini P, Pflumio F (2010) Leukemia 24: 646-9

Viral entry and escape from antibody-mediated neutralization influence hepatitis C virus reinfection in liver transplantation. Fafi-Kremer S, Fofana I, Soulier E, Carolla P, Meuleman P, Leroux-Roels G, Patel AH, Cosset FL, Pessaux P, Doffoel M, Wolf P, Stoll-Keller F, Baumert TF (2010) The Journal of experimental medicine 207: 2019-31

Characterization of hepatitis C virus pseudoparticles by cryo-transmission electron microscopy using functionalized magnetic nanobeads. Bonnafous P, Perrault M, Le Bihan O, Bartosch B, Lavillette D, Penin F, Lambert O, Pecheur EI (2010) The Journal of general virology 91: 1919-30

Porcine endogenous retroviruses PERV A and A/C recombinant are insensitive to a range of divergent mammalian TRIM5 alpha proteins including human TRIM5 alpha. Wood A, Webb BLJ, Bartosch B, Schaller T, Takeuchi Y, Towers GJ (2009) Journal of General Virology 90: 702-709

Kinases required in hepatitis C virus entry and replication highlighted by small interference RNA screening. Trotard M, Lepere-Douard C, Regeard M, Piquet-Pellorce C, Lavillette D, Cosset FL, Gripon P, Le Seyec J (2009) Faseb J 23: 3780-9

DNA Vaccination with a Single-Plasmid Construct Coding for Viruslike Particles Protects Mice against Infection with a Highly Pathogenic Avian Influenza A Virus. Szecsi J, Gabriel G, Edfeldt G, Michelet M, Klenk HD, Cosset FL (2009) The Journal of infectious diseases 200: 181-90

Role of adiponectin receptors, AdipoR1 and AdipoR2, in the steroidogenesis of the human granulosa tumor cell line, KGN. Pierre P, Froment P, Negre D, Rame C, Barateau V, Chabrolle C, Lecomte P, Dupont J (2009) Human reproduction (Oxford, England) 24: 2890-901

Amphipathic DNA polymers inhibit hepatitis C virus infection by blocking viral entry. Matsumura T, Hu Z, Kato T, Dreux M, Zhang YY, Imamura M, Hiraga N, Juteau JM, Cosset FL, Chayama K, Vaillant A, Liang TJ (2009) Gastroenterology 137: 673-81

Mouse ES cells over-expressing the transcription factor NeuroD1 show increased differentiation towards endocrine lineages and insulin-expressing cells. Marchand M, Schroeder IS, Markossian S, Skoudy A, Negre D, Cosset FL, Real P, Kaiser C, Wobus AM, Savatier P (2009) The International journal of developmental biology 53: 569-78

A cell-based bicistronic lentiviral reporter system for identification of inhibitors of the hepatitis C virus internal ribosome entry site. Lourenco S, Boni S, Furling D, Cosset FL, Cahour A (2009) Journal of virological methods 158: 152-159

Single-chain antibodies that target lentiviral vectors to MHC class II on antigen-presenting cells. Gennari F, Lopes L, Verhoeyen E, Marasco W, Collins MK (2009) Human gene therapy 20: 554-62

Efficient and stable transduction of resting B-lymphocytes and primary chronic lymphocyte leukemia cells using measles virus gp displaying lentiviral vectors. Frecha C, Costa C, Levy C, Negre D, Russell SJ, Maisner A, Salles G, Peng KW, Cosset* FL, Verhoeyen* E (2009) Blood 114: 3173-3180

Receptor complementation and mutagenesis reveal SR-BI as an essential HCV entry factor and functionally imply its intra- and extra-cellular domains. Dreux M, Dao Thi VL, Fresquet J, Guerin M, Julia Z, Verney G, Durantel D, Zoulim F, Lavillette D, Cosset* FL, Bartosch* B (2009) PLoS pathogens 5: e1000310

Recombinant retrovirus-like particle forming DNA vaccines in prime-boost immunization and their use for hepatitis C virus vaccine development. Desjardins D, Huret C, Dalba C, Kreppel F, Kochanek S, Cosset FL, Tangy F, Klatzmann D, Bellier B (2009) The journal of gene medicine 11: 313-25

The TLR1/2 agonist PAM(3)CSK(4) instructs commitment of human hematopoietic stem cells to a myeloid cell fate. De Luca K, Frances-Duvert V, Asensio MJ, Ihsani R, Debien E, Taillardet M, Verhoeyen E, Bella C, Lantheaume S, Genestier L, Defrance T (2009) Leukemia 23: 2063-2074

Characterization of Lassa virus cell entry and neutralization with Lassa virus pseudoparticles. Cosset FL, Marianneau P, Verney G, Gallais F, Tordo N, Pecheur EI, ter Meulen J, Deubel V, Bartosch B (2009) Journal of virology 83: 3228-37

Ciliary beating recovery in deficient human airway epithelial cells after lentivirus ex vivo gene therapy. Chhin B, Negre D, Merrot O, Pham J, Tourneur Y, Ressnikoff D, Jaspers M, Jorissen M, Cosset FL, Bouvagnet P (2009) PLoS Genet 5: e1000422

The IG domain protein CD9P-1 down-regulates CD81 ability to support plasmodium YOELII infection. Charrin S, Yalaoui S, Bartosch B, Cocquerel L, Franetich JF, Boucheix C, Mazier D, Rubinstein E, Silvie O (2009) The Journal of biological chemistry

The tight junction-associated protein occludin is required for a postbinding step in hepatitis C virus entry and infection. Benedicto I, Molina-Jimenez F, Bartosch B, Cosset FL, Lavillette D, Prieto J, Moreno-Otero R, Valenzuela-Fernandez A, Aldabe R, Lopez-Cabrera M, Majano PL (2009) Journal of virology 83: 8012-20

Evidence for protection against chronic hepatitis C virus infection in chimpanzees by immunization with replicating recombinant vaccinia virus. Youn JW, Hu YW, Tricoche N, Pfahler W, Shata MT, Dreux M, Cosset FL, Folgori A, Lee DH, Brotman B, Prince AM (2008) Journal of virology 82: 10896-905

Polyclonal immunoglobulins from a chronic hepatitis C virus patient protect human liver-chimeric mice from infection with a homologous hepatitis C virus strain. Vanwolleghem T, Bukh J, Meuleman P, Desombere I, Meunier JC, Alter H, Purcell RH, Leroux-Roels G (2008) Hepatology (Baltimore, Md 47: 1846-55

The tight junction proteins claudin-1, -6 and -9 are entry cofactors for the Hepatitis C virus. Meertens L, Bertaux C, Cukierman L, Cormier E, Lavillette D, Cosset FL, Dragic T (2008) Journal of virology 82: 3555-3560

A point mutation leading to hepatitis C virus escape from neutralization by a monoclonal antibody to a conserved conformational epitope. Keck ZY, Olson O, Gal-Tanamy M, Xia J, Patel AH, Dreux M, Cosset FL, Lemon SM, Foung SK (2008) Journal of virology 82: 6067-72

Neutralizing host responses in hepatitis C virus infection target viral entry at postbinding steps and membrane fusion. Haberstroh A, Schnober EK, Zeisel MB, Carolla P, Barth H, Blum HE, Cosset FL, Koutsoudakis G, Bartenschlager R, Union A, Depla E, Owsianka A, Patel AH, Schuster C, Stoll-Keller F, Doffoel M, Dreux M, Baumert TF (2008) Gastroenterology 135: 1719-1728 e1

Improved lentiviral vectors for Wiskott-Aldrich syndrome gene therapy mimic endogenous expression profiles throughout haematopoiesis. Frecha C, Toscano MG, Costa C, Saez-Lara MJ, Cosset FL, Verhoeyen E, Martin F (2008) Gene therapy 15: 930-41

Stable transduction of quiescent T cells without induction of cycle progression by a novel lentiviral vector pseudotyped with measles virus glycoproteins. Frecha C, Costa C, Negre D, Gauthier E, Russell SJ, Cosset* FL, Verhoeyen* E (2008) Blood 112: 4843-52

Contribution of redox status to hepatitis C virus e2 envelope protein function and antigenicity. Fenouillet E, Lavillette D, Loureiro S, Krashias G, Maurin G, Cosset FL, Jones IM, Barbouche R (2008) The Journal of biological chemistry 283: 26340-8

Reconstitution of the myeloid and lymphoid compartments after the transplantation of autologous and genetically modified CD34+ bone marrow cells, following gamma irradiation in cynomolgus macaques. Derdouch S, Gay W, Negre D, Prost S, Le Dantec M, Delache B, Auregan G, Andrieu T, Leplat JJ, Cosset FL, Le Grand R (2008) Retrovirology 5: 50


Revues et Chapitres de livres (depuis)


Gene Therapy in Fanconi anemia: a matter of time, safety and gene transfer tool efficiency. Verhoeyen E, Rodriguez FJ, Cosset FL, Levy C, Rio P (2017) Curr Gene Ther

A master regulator of tight junctions involved in hepatitis C virus entry and pathogenesis. Denolly S, Cosset FL (2017) Hepatology 65: 1756-1758

Addressing the next challenges: A summary of the 22nd international symposium on hepatitis C virus and related viruses. Baumert TF, Schuster C, Cosset FL, Dubuisson J, Hofmann M, Tautz N, Zeisel MB, Thimme R (2016) J Hepatol 64: 968-73

Towards an HBV cure: state-of-the-art and unresolved questions-report of the ANRS workshop on HBV cure. Zeisel MB, Lucifora J, Mason WS, Sureau C, Beck J, Levrero M, Kann M, Knolle PA, Benkirane M, Durantel D, Michel ML, Autran B, Cosset FL, Strick-Marchand H, Trepo C, Kao JH, Carrat F, Lacombe K, Schinazi RF, Barre-Sinoussi F et al. (2015) Gut 64: 1314-26

Surface engineering of lentiviral vectors for gene transfer into gene therapy target cells. Levy C, Verhoeyen E, Cosset FL (2015) Curr Opin Pharmacol 24: 79-85

The mechanism of HCV entry into host cells. Douam F, Lavillette D, Cosset FL (2015) Prog Mol Biol Transl Sci 129: 63-107

Regulation of the Host Antiviral State by Intercellular Communications. Assil S, Webster B, Dreux M (2015) Viruses 7: 4707-33

Virology and cell biology of the hepatitis C virus life cycle – An update. Dubuisson J, Cosset FL (2014) J Hepatol 61: S3-S13

HCV transmission by hepatic exosomes establishes a productive infection. Cosset FL, Dreux M (2014) J Hepatol 60: 674-675

[Modulation of permissiveness and antiviral response against hepatitis C virus by interferon lambda-associated polymorphism]. Assil S, Dreux M (2014) Med Sci (Paris) 30: 1073-5

[Exosomes are carriers for immunostimulatory viral RNA]. Assil S, Decembre E, Dreux M (2013) Med Sci (Paris) 29: 104-6

Verhoeyen E, Cosset FL (2012) Novel lentiviral vector pseudotypes for stable gene transfer into resting hematopoietic cells.

Advances in foamy virus vector technology and disease correction could speed the path to clinical application. Verhoeyen E (2012) Mol Ther 20: 1105-7

Gene therapy for fanconi anemia: one step closer to the clinic. Tolar J, Becker PS, Clapp DW, Hanenberg H, de Heredia CD, Kiem HP, Navarro S, Qasba P, Rio P, Schmidt M, Sevilla J, Verhoeyen E, Thrasher AJ, Bueren J (2012) Hum Gene Ther 23: 141-4

Guidelines for the use and interpretation of assays for monitoring autophagy. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J et al. (2012) Autophagy 8: 445-544

Production of SIV Vectors for Gene Delivery. Verhoeyen E, Cosset FL, Negre D (2011) Cold Spring Harb Protoc 2011: pdb prot5598

Stem cell gene therapy for fanconi anemia: report from the 1st international Fanconi anemia gene therapy working group meeting. Tolar J, Adair JE, Antoniou M, Bartholomae CC, Becker PS, Blazar BR, Bueren J, Carroll T, Cavazzana-Calvo M, Clapp DW, Dalgleish R, Galy A, Gaspar HB, Hanenberg H, Von Kalle C, Kiem HP, Lindeman D, Naldini L, Navarro S, Renella R et al. (2011) Mol Ther 19: 1193-8

A comparative portrait of retroviral fusogens and syncytins. Pérot P, Montgiraud, C, Lavillette, D and Mallet, F (2011) Cell Fusions book, Sringer

Too smart to fail-how viruses exploit the complexity of host cells during entry. Greber UF, Cosset FL (2011) Curr Opin Virol 1: 3-5

Lentiviral vectors. Giry-Laterriere M, Verhoeyen E, Salmon P (2011) Methods Mol Biol 737: 183-209

In vivo gene delivery into hCD34+ cells in a humanized mouse model. Frecha C, Fusil F, Cosset FL, Verhoeyen E (2011) Methods Mol Biol 737: 367-90

Impact of the autophagy machinery on hepatitis C virus infection. Dreux M, Chisari FV (2011) Viruses 3: 1342-57

Scavenger receptor class B type I and the hypervariable region-1 of hepatitis C virus in cell entry and neutralisation. Dao Thi VL, Dreux* M, Cosset* FL (2011) Expert Rev Mol Med 13: e13

Cell entry of enveloped viruses. Cosset FL, Lavillette D (2011) Adv Genet 73: 121-83

HCV research 20 years after discovery: a summary of the 16th international symposium on hepatitis C virus and related viruses. Pawlotsky JM CL, Durantel D, Lavillette D, Lerat H, Pécheur EI, Polyak SJ, Tautz N, Thimme R (2010) Gastroenterology 138: 6-12

Advances in the Field of Lentivector-based Transduction of T and B Lymphocytes for Gene Therapy. Frecha C, Levy C, Cosset* FL, Verhoeyen* E (2010) Mol Ther 18: 1748-1757

Hepatitis C virus replication cycle. Bartenschlager* R, Cosset* FL, Lohmann V (2010) J Hepatol 53: 583-5

Lentiviral vector gene transfer into human T cells. Verhoeyen E, Costa C, Cosset FL (2009) Methods Mol Biol 506: 97-114

Hematopoietic stem cell targeting with surface-engineered lentiviral vectors. Verhoeyen E, Cosset FL (2009) CSH Protoc 2009: pdb prot5276

Engineering the surface glycoproteins of lentiviral vectors for targeted gene transfer. Verhoeyen E, Cosset FL (2009) CSH Protoc 2009: pdb top59

Detection of Neutralizing Antibodies with HCV Pseudoparticles (HCVpp). Dreux M, Cosset FL (2009) Methods Mol Biol 510: 427-38

Viral vectors: from virology to transgene expression. Bouard D, Alazard-Dany N, Cosset F-L (2009) British Journal of Pharmacology 157: 153–165

Studying HCV Cell Entry with HCV Pseudoparticles (HCVpp). Bartosch B, Cosset FL (2009) Methods Mol Biol 510: 279-93

Host neutralizing responses and pathogenesis of hepatitis C virus infection. Zeisel MB, Cosset FL, Baumert TF (2008) Hepatology 48: 299-307

Production of lentiviruses displaying  »early-acting » cytokines for selective gene transfer into hematopoietic stem cells. Verhoeyen E, Negre D, Cosset FL (2008) Methods Mol Biol 434: 99-112

Strategies for targeting lentiviral vectors. Frecha C, Szecsi J, Cosset* FL, Verhoeyen* E (2008) Curr Gene Ther 8: 449-60


Brevets (depuis 2008)

Lentiviral vectors for targeting human CD34+ cells. Verhoeyen Els, François-Loic Cosset, Cecilia Frecha and Caroline Costa. Patent application EP – 07 290918.7. Filling Date: 23.07.2007. Applicant: INSERM. Exclusive license in 2011 (Lentigen). Exclusive license in 2014 (Milteniy).

Arabinogalactanes, Apiogalacturonanes et Hétéroglycanes sulfates pour le traitement des maladies causées par les virus influenza. Demande de Brevet Français déposée le 4 janvier 2011. FR 1150049. Exclusive license in 2011.

New Lentiviral vector pseudotyped with mutant BAEV glycoproteins allow efficient gene transfer of hematopoietic cells. Verhoeyen E, Girard A, Lavillette D, Fl cosset. Patent application EP N°11 306 247.5. Filling Date: 29.09.2011. Applicant: INSERM. Exclusive license in 2012. Brevet délivré aux USA le 02 Feb 2016 sous le N° 9,249,426. Exclusive license in 2012 (Lentigen). Exclusive license in 2014 (Milteniy).

Chimeric pseudo-particles containing functional hMPV proteins. Levy Camille, Cosset François-Loic. Patent application N° EP12305283.9. Filling Date: 9.03.2012. PCT/EP2013/05489. Applicant: ENS Lyon.

Lentiviral vector expressing membrane-anchored or secreted antibody. Floriane Fusil, Els Verhoeyen, Thierry Defrance, François-Loic Cosset. Patent application N° EP15306132.0. PCT/EP2016/066349. Filling Date: 9 July 2015. Applicant: Inserm.

Methods for selectively modulating the activity of distinct subtypes of cells. Demande de brevet N°EP16305468.7 le 21 avril 2016 aux noms de l’ENS de Lyon, du CNRS, de l’INSERM et de l’UCBL