Plasmacytoid dendritic cells control dengue and Chikungunya virus infections via IRF7-regulated interferon responses.

Auteurs:

Webster B#1, Werneke SW#2,3, Zafirova B2, This S1, Coléon S1, Décembre E1, Paidassi H1, Bouvier I2, Joubert PE2, Duffy D2, Walzer T1, Albert ML2,3, Dreux M1.

Actualité Inserm à propos de l’article:

https://www.inserm.fr/actualites-et-evenements/actualites/dengue-et-chikungunya-cellules-minoritaires-cle-controle-infection

Résumé vulgarisé:

Titre: Les cellules dendritiques plasmacytoïdes en première ligne dans la lutte contre les virus de la Dengue et du Chickungunya

Résumé vulgarisé

Résumé:

Type I interferon (IFN-I) responses are critical for the control of RNA virus infections, however, many viruses, including Dengue (DENV) and Chikungunya (CHIKV) virus, do not directly activate plasmacytoid dendritic cells (pDCs), robust IFN-I producing cells. Herein, we demonstrated that DENV and CHIKV infected cells are sensed by pDCs, indirectly, resulting in selective IRF7 activation and IFN-I production, in the absence of other inflammatory cytokine responses. To elucidate pDC immunomodulatory functions, we developed a mouse model in which IRF7 signaling is restricted to pDC. Despite undetectable levels of IFN-I protein, pDC-restricted IRF7 signaling controlled both viruses and was sufficient to protect mice from lethal CHIKV infection. Early pDC IRF7-signaling resulted in amplification of downstream antiviral responses, including an accelerated natural killer (NK) cell-mediated type II IFN response. These studies revealed the dominant, yet indirect role of pDC IRF7-signaling in directing both type I and II IFN responses during arbovirus infections.

Découvrez l’équipe VIV « Traffic Vésiculaire, réponse Innée et Virus »dirigée par Marlène Dreux.

Référence et lien vers l’article:

Elife. 2018 Jun 19;7. pii: e34273. doi: 10.7554/eLife.34273.

Lien vers l’article.

Affiliations des auteurs:

1- CIRI, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, Univ Lyon, Lyon, France

2- Immunobiology of Dendritic Cells, Institut Pasteur, Paris, France.

3- Cancer Immunology Department, Genentech, San Francisco, United States.

# Contributed equally

 

NOS TUTELLES ET PARTENAIRES