European UE “Virus & Immunity”

VIRUS AND IMMUNITY, European teaching unit

The “Virus & Immunity” Course is organized as part of the European Master-Biosciences program in Lyon, France.

Sponsored by:

04_Enseignement_Sponsored by for virus Immunité

Coordinators of the course: Branka HORVAT ; Viktor VOLCHKOV

Course « Virus and Immunity » is organized for the first time in April 2005, as a part of « European » teaching unit. It is open to students of « Masters » in at Ecole Normale Supérieure de Lyon and University Lyon 1 as well as to any other exchange students, particularly those from other European countries and intended to stimulate international students participation.

The course consists of 40h of lectures and 10h of tutorials (giving 6 credits ECTS). All lectures are given on english by the experts in the field (three Nobel prize laureates among lecturers in last years) and are based on the interactive approach between lecturers and students. Tutorials are supposed to help students to better understand subjects treated during lectures. Organized teaching approach is supposed to guide students in the analysis of research articles and in preparing a short research project based on one of conferences. The major goal of the course is to stimulate the originality in students and help developing their passion for the research and creative approach in the science, by guiding them through the universe of the complex interactions between the virus and the immune system.

Program of the course:

The course covers different aspects of fundamental virology and immunology and particular attention is put on the interaction between virus and immune system. Treated subjects include analysis of biochemical and structural aspects of the virus, variability and genetics, basic concepts in the prion research, response to anti-viral treatment and generation of the resistance to therapy. Presented studies include the research work on several different viruses, including causative agent of AIDS in humans and of leukaemia in mice, hepatitis B and C virus, Infuenza, Measles virus, Human T-cell Lymphotropic virus and emergent viruses classified at the highest level of security (P4), including Ebola, Lassa, SARS, Nipah and Hendra viruses. Particular attention is put on the presentation of the importance of different self-defence mechanisms to eliminate infection, including dendritic cells, T and NK lymphocytes as well as mechanisms important in the control of the extent of the immune response, like T regulatory lymphocytes. Generation of T cell repertoire, immunological memory, modulation of the immune response, virus escape mechanisms, immunosuppression and viral persistence is illustrated. Finally, viral pathogenesis and anti-viral vaccination is discussed.

Direct access to:


2016 Programme

1-12/02/2016, amphitheater « Biologie », ENS-Lyon, France
Monday 1/02
9H30-10H Introduction (V. Volchkov, B. Horvat, CIRI, INSERM U1111, Lyon)

10H-12H Grant McFADDEN (Depart. Molecular Genetics and Microbiology, University of
Florida, USA), LabEx ECOFECT
«Lessons from Myxoma Virus on Viral-Host Ecology and Co-evolution»

14H-16H30 Alexandra R. LUCAS (University of Florida, USA)
“Viral Immune Modulators – Guides to New Drug Discovery ».

Tuesday 2/02
9H30-12H Sandra JUNGLEN (Institut of Virology, Bonn, Germany, LabEx ECOFECT.
« Evolutionary and ecological insights into the emergence of arthropod-borne viruses »

14H-16H30 Siamon GORDON (Sir William Dunn School of Pahtology, University of Oxford, UK) « The Versatile Macrophage: Immunobiology/virology»

Wednesday 3/02
9H30-12H Branka HORVAT (CIRI, INSERM U1111, ECOFECT, Lyon)
«Emerging contagion: immunopathogenesis of Nipah virus infection»

14H-16H30 Thierry WALZER (CIRI, INSERM U1111, Lyon)
« NK cells in the control of infections »

Thursday 4/02
9H30-12H Adrian HAYDAY (Guy’s King’s & St Thomas Medical School, London, UK)
« Gamma Delta T cell responses bridge innate and adaptive immunity »

14H-16H30 Daniel GONZALEZ-DUNIA (INSERM, UMR 1043, Toulouse)
« A journey through the interactions between viruses and the brain: advantages and challenges of the Bornavirus paradigm ».

Friday 5/02
9H30-12H Julien C. MARIE (Cancer Research Center, Lyon, INSERM 1052 CNRS 5286)
« Regulation of T lymphocytes: role of Treg and TGF-beta »

14H30-17H Maan ZREIN (INFYNITY-BIOMARKERS, Lyon, France)
« Converting academic research into industrial applications: Design of diagnostics assays with a focus on virology »

2nd week

Monday 8/02
9H30-12H Benedikt KAUFER (Institute of Virology, Berlin, Germany)
« Herpesvirus latency: From neuronal models to integration into host telomeres. »


Tuesday 9/02
9H30-12H Daniel KOLAKOFSKY (Department of Microbiology and Molecular Medicine, University of Geneva Medical School, Geneva, Switzerland :
« A short biased history of RNA viruses

14H-16H30 Patrick LOMONTE (Institut NeuroMyoGène, INSERM-U1217, CNRS/UCBL, Villeurbanne, France)
« Immune and epigenetic control of herpes simplex virus latency»

Wednesday 10/02
9h30-12H Sander HERFST (Department of Viroscience, Erasmus Medical Centre, Netherlands)
« Influenza: From zoonoses to pandemics»

14H-16H30 François-Loïc COSSET (CIRI, INSERM U1111, ECOFECT, Lyon)
« HCV-lipid metabolism interconnections and virus propagation: opportunities for the development of novel antiviral strategies »

Thursday 11/02
9H30-12H Viktor VOLCHKOV (CIRI, INSERM U1111, ECOFECT, Lyon)
« Filoviruses: Molecular basis of the pathogenicity».

Lecturers in the periode 2005 – 2012 :

Mathiew ALBERT (Institut Pasteur, Paris)
Henri AGUT (Hôpital Pitié-Salpêtrière, Université Paris 6, France), Video
Sebastian AMIGORENA (Institut Curie, INSERM, Paris, France)
Lena ALEXOPOULOU (CIML, Marsielle, France), Video
Patrice ANDRE (INSERM, Lyon, France)
Jacques BANCHERAU (Baylor Institute for Immunology Research, Dalas, USA),
Françoise BARRE-SINOUSSI (Nobel Prize Laureate in 2008, Institute Pasteur, Paris), Video
Chritopher BASLER (Dept. Microbiology, Mount Sinai Medical School, New York, USA)
Stephan BECKER (Marbourg, Germany)
Pierre BOULANGER (UMR, Lyon, France)
Claude CARNAUD (INSERM Univ. Paris 6, UMRS 938, St Antoine Hospital, Paris)
Roberto CATTANEO (Mayo Clinic, Rochester, USA), Video
Cristophe CAUX (INSERM U590, Centre Léon-Bérard, Lyon)
Klaus CONZELMANN (Max von Pettenkofer Inst. and Gene Cent., Munich, Germany)
Louise COSBY (Belfast, UK)
François-Loïc COSSET (INSERM, Lyon, France), Video
Jean-Luc DARLIX (INSERM, Lyon, France), Video
Christian DAVRINCHE (INSERM, Toulouse, France)
Christian DROSTEN (Institut of Virology, University of Bonn Medical Centre, Bonn, Germany)
Peter C. DOHERTY (Nobel Prize Laureate in Medicine, 1996), Melbourne, Australia), Slides
Richard ELLIOTT (Centre for Biomolecular Sciences, University of St Andrews,UK), Video
Luis ENJUANES  (National Biotechnological center, Madrid, Spain), Video
Heinz FELDMANN (National Institute of Health, NIH, Montana, USA)
Matias FAURE (INSERM U851, Lyon, France)
Ilya FROLOV (Texas University, USA), Video
Carleton GAJDUSEK (Nobel Prize Laureat in Medicine, NIH)
Adolfo GARCIA-SASTRE (Depart of Microbiology, Mount Sinai School of Medicine, New York, USA)
Teunis B.H. GEIJTENBEEK (University of Amsterdam, Netherlands), Video
Daniel GONZALES-DUNIA (INSERM U563, Toulouse), Video
Yves GAUDIN (Structural and Molecular Virology, CNRS, Gif sur Yvette, France)
Louis GAZZOLO (INSERM, Lyon, France)
Tom GEISBERT (NEIDL, Boston, USA), Video
Denis GERLIER (CNRS UCBL, Lyon, France)
Otto HALLER (Department of Virology, University of Freiburg, Germany), Video
Uzma HASAN (INSERM U851, Lyon)
Adrian HAYDAY (Guy’s King’s & St Thomas Medical School, King’s College London), Video
Franz HEINZ (Institute of Virology, Vienna, Austria)
Anne HOSMALIN (Cochin Institute, Paris)
Stipe JONJIC (University of Rijeka, Croatie)
Dominique KAISERLIAN (INSERM, Lyon, France)
Ulrich KALINKE (TWINCORE, Centre of Exp. and Clinical Infection Research, Hannover, Germany)
Nikolay KAVERIN (Institute of Virology, Russian Academy of Med. Sciences, Russia)
Hans Dieter KLENK (Marburg, Germany)
Jean-Pierre KRAEHENBUHL  (ISREC, Switzerland)
Robert LAMB (Deptement of Molecular Biosciences, Northwestern University, Evanston, USA), Video
Serge LEBECQUE (INSERM, Lyon, France)
Vincent LOTTEAU (INSERM, Lyon, France)
Roland LIBLAU (INSERM-U563 Centre de Physiopathologie de Toulouse Purpan)
Paolo LUSSO (NIH, USA), Video
Andrew McMICHAEL, (Oxford, UK), Video
Renaud MAHIEUX (INSERM 758, Lyon, France)
Ziad MALLAT (INSERM, Paris, France)
Julien C. MARIE , (Cancer  Research Center of Lyon, UMR Inserm U1052 CNRS 5286)
Jacqueline MARVEL (INSERM, Lyon, France)
Janet MARYANSKI (INSERM, Lyon, France)
Mary MALISSEN (CIML, Marseille, France)
Mikhail MATROSOVICH (Marburg, Germany)
Matteo NEGRONI, (CNRS-UPR 9002, Strasbourg, France)
Daniel D. PINSCHEWER (Dept. of Pathology and Immunology, University of Geneva), Video
Matteo POROTTO (Dept Micorbiol and Immunology, Weill Cornell Medical College, New York, USA)
Laurent ROUX (University of Geneva, Switzerland)
Alexander PLYUSNIN, (Haartman Institute, Department of Virology, University of Helsinki, Finland)
Beneditta ROCHA (Necker Institut, INSERM U591, Paris, France), Video
Polly ROY (London School of Hygiene & Tropical Medicine, UK), Video
Rob RUIGROCK (UJF, Grenoble, France)
Anna SALVETTI (INSERM, Lyon, France)
Benoît SALOMON (INSERM, Hôpital de la Pitié-Salpêtrière, Paris)
Quentin SATTENTAU (The Sir William Dunn School of Pathology, University of Oxford, UK), Video
Peter STAHEALI (University of Freiburg, Germany)
Alain TRAUTMANN (Institut Cochin, Paris, France), Video
Noël TORDO (Institut Pasteur, France), Video
Luk VANDENBERGHE, (Deptement of Pathology, University of Pennsylvania, USA)
Eric VIVIER (CIML, Marseille, France)
Thierry WALZER (CIML, Marseille, France), Video
Friedmann WEBER (University of Freiburg, Germany)
Jean-Claude WEIL (Hopital Necker, Paris, France), Video
Fabian WILD (INSERM, Lyon, France)
Fabien ZOULIM (INSERM, Lyon, France)